更快、更高、更强：干细胞谱系中及时而强大的细胞命运/身份承诺。

Faster, higher, stronger: timely and robust cell fate/identity commitment in stem cell lineages.

机构信息

1 Ministry of Education Key Laboratory of Cell Proliferation and Differentiation, School of Life Sciences , Beijing 100871 , People's Republic of China.

2 Peking-Tsinghua Center for Life Sciences, Peking University , Beijing 100871 , People's Republic of China.

出版信息

Open Biol. 2019 Feb 28;9(2):180243. doi: 10.1098/rsob.180243.

DOI:10.1098/rsob.180243

PMID:30958098

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6395883/

Abstract

Precise specification of cell fate or identity within stem cell lineages is critical for ensuring correct stem cell lineage progression and tissue homeostasis. Failure to specify cell fate or identity in a timely and robust manner can result in developmental abnormalities and diseases such as cancer. However, the molecular basis of timely cell fate/identity specification is only beginning to be understood. In this review, we discuss key regulatory strategies employed in cell fate specification and highlight recent results revealing how timely and robust cell fate/identity commitment is achieved through transcriptional control.

摘要

精确指定干细胞谱系中的细胞命运或身份对于确保正确的干细胞谱系进展和组织内稳态至关重要。如果不能及时、有效地指定细胞命运或身份，可能会导致发育异常和癌症等疾病。然而，细胞命运/身份及时指定的分子基础才刚刚开始被理解。在这篇综述中，我们讨论了细胞命运指定中采用的关键调控策略，并强调了最近的研究结果，这些结果揭示了通过转录控制如何实现及时和有效的细胞命运/身份承诺。