Tiwari Sanjay, Patil Rahul, Bahadur Pratap
Maliba Pharmacy College, UKA Tarsadia University, Gopal-Vidyanagar Campus, Surat 394350, Gujarat, India.
Chemistry Department, Veer Narmad South Gujarat University, Surat 395007, Gujarat, India.
Polymers (Basel). 2018 Dec 20;11(1):1. doi: 10.3390/polym11010001.
Soft tissue reconstructs require materials that form three-dimensional (3-D) structures supportive to cell proliferation and regenerative processes. Polysaccharides, due to their hydrophilicity, biocompatibility, biodegradability, abundance, and presence of derivatizable functional groups, are distinctive scaffold materials. Superior mechanical properties, physiological signaling, and tunable tissue response have been achieved through chemical modification of polysaccharides. Moreover, an appropriate formulation strategy enables spatial placement of the scaffold to a targeted site. With the advent of newer technologies, these preparations can be tailor-made for responding to alterations in temperature, pH, or other physiological stimuli. In this review, we discuss the developmental and biological aspects of scaffolds prepared from four polysaccharides, viz. alginic acid (ALG), chitosan (CHI), hyaluronic acid (HA), and dextran (DEX). Clinical studies on these scaffolds are also discussed.
软组织重建需要能够形成支持细胞增殖和再生过程的三维（3-D）结构的材料。多糖因其亲水性、生物相容性、生物降解性、丰富性以及存在可衍生的官能团，是独特的支架材料。通过多糖的化学修饰已实现了优异的机械性能、生理信号传导和可调的组织反应。此外，适当的配方策略能够将支架在空间上放置到目标部位。随着新技术的出现，这些制剂可以量身定制以响应温度、pH值或其他生理刺激的变化。在本综述中，我们讨论了由四种多糖，即海藻酸（ALG）、壳聚糖（CHI）、透明质酸（HA）和葡聚糖（DEX）制备的支架的发展和生物学方面。还讨论了这些支架的临床研究。
