Liu Pengfei, Pearce Charles M, Anastasiadi Rozalia-Maria, Resmini Marina, Castilla Ana M
Department of Chemistry and Biochemistry, SBCS, Queen Mary University of London, Mile End Road, London E1 4NS, UK.
Polymers (Basel). 2019 Feb 18;11(2):353. doi: 10.3390/polym11020353.
Covalently crosslinked nanogels are widely explored as drug delivery systems and sensors. Radical polymerization provides a simple, inexpensive, and broadly applicable approach for their preparation, although the random nature of the reaction requires careful study of the final chemical composition. We demonstrate how the different reactivities of the monomers influence the total degree of incorporation into the polymer matrix and the role played by the experimental parameters in maximizing polymerization efficiency. Nanogels based on -isopropylacrylamide, --propylacrylamide, and acrylamide crosslinked with -methylenebisacrylamide were included in this study, in combination with functional monomers -acryloyl-l-proline, 2-acrylamido-2-methyl-1-propanesulfonic acid, and 4-vinyl-1-imidazole. Total monomer concentration and initiator quantities are determining parameters for maximizing monomer conversions and chemical yields. The results show that the introduction of functional monomers, changes in the chemical structure of the polymerizable unit, and the addition of templating molecules can all have an effect on the polymerization kinetics. This can significantly impact the final composition of the matrices and their chemical structure, which in turn influence the morphology and properties of the nanogels.
共价交联纳米凝胶作为药物递送系统和传感器受到广泛研究。自由基聚合为其制备提供了一种简单、廉价且广泛适用的方法，尽管反应的随机性需要仔细研究最终的化学成分。我们展示了单体的不同反应活性如何影响其掺入聚合物基质的总程度，以及实验参数在最大化聚合效率中所起的作用。本研究包括基于N-异丙基丙烯酰胺、N,N-二丙基丙烯酰胺和与N,N'-亚甲基双丙烯酰胺交联的丙烯酰胺的纳米凝胶，以及功能性单体N-丙烯酰-L-脯氨酸、2-丙烯酰胺基-2-甲基-1-丙磺酸和4-乙烯基-1-咪唑。总单体浓度和引发剂用量是最大化单体转化率和化学产率的决定性参数。结果表明，功能性单体的引入、可聚合单元化学结构的变化以及模板分子的添加都会对聚合动力学产生影响。这会显著影响基质的最终组成及其化学结构，进而影响纳米凝胶的形态和性能。
