文献检索文档翻译深度研究
Suppr Zotero 插件Zotero 插件
邀请有礼套餐&价格历史记录

新学期，新优惠

限时优惠:9月1日-9月22日

30天高级会员仅需29元

1天体验卡首发特惠仅需5.99元

了解详情
不再提醒
插件&应用
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
高级版
套餐订阅购买积分包
AI 工具
文献检索文档翻译深度研究
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

用于肿瘤靶向给药的pH激活电荷反转聚合物修饰的氧化锌量子点

ZnO Quantum Dots Modified by pH-Activated Charge-Reversal Polymer for Tumor Targeted Drug Delivery.

作者信息

Wang Yifan, He Liang, Yu Bing, Chen Yang, Shen Youqing, Cong Hailin

机构信息

Institute of Biomedical Materials and Engineering, College of Materials Science and Engineering, College of Chemistry and Chemical Engineering, Qingdao University, Qingdao 266071, China.

Laboratory for New Fiber Materials and Modern Textile, Growing Base for State Key Laboratory, Qingdao University, Qingdao 266071, China.

出版信息

Polymers (Basel). 2018 Nov 15;10(11):1272. doi: 10.3390/polym10111272.

DOI:10.3390/polym10111272
PMID:30961197
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6401959/
Abstract

In this paper, we reported a pH responsive nano drug delivery system (NDDS) based on ZnO quantum dots (QDs) for controlled release of drugs. Zwitterionic poly(carboxybetaine methacrylate) (PCBMA) and poly(2-(dimethylamino) ethyl methacrylate) (PDMAEMA) were introduced to modify ZnO QDs, which can help enhance water stability, increase blood circulation time, and promote endocytosis. After tuning of PCBMA/PDMAEMA ratios, the ZnO@P(CBMADMAEMA) nanoplatform shows a sensitive switch from strong protein adsorption resistance (with negatively charged surface) at physiological pH to strong adhesion to tumor cell membranes (with positively charged surface) at the slightly acidic extracellular pH of tumors. Anti-cancer drug, Doxorubicin (DOX), molecules were demonstrated to be successfully loaded to ZnO@P(CBMADMAEMA) with a relatively large drug loading content (24.6%). In addition, ZnO@P(CBMADMAEMA) loaded with DOX can achieve lysosomal acid degradation and release of DOX after endocytosis by tumor cells, resulting in synergistic treatment of cancer, which is attributed to a combination of the anticancer effect of Zn and DOX.

摘要

在本文中，我们报道了一种基于氧化锌量子点（QDs）的pH响应型纳米药物递送系统（NDDS），用于药物的控释。引入两性离子聚（甲基丙烯酸羧酸甜菜碱）（PCBMA）和聚（甲基丙烯酸2-（二甲氨基）乙酯）（PDMAEMA）对氧化锌量子点进行修饰，这有助于提高其水稳定性、延长血液循环时间并促进内吞作用。通过调整PCBMA/PDMAEMA的比例，ZnO@P（CBMADMAEMA）纳米平台表现出一种敏感的转变，即从生理pH下具有强抗蛋白质吸附能力（表面带负电荷）转变为在肿瘤微酸性细胞外pH下对肿瘤细胞膜具有强粘附性（表面带正电荷）。抗癌药物阿霉素（DOX）分子被证明能够以相对较高的载药量（24.6%）成功负载到ZnO@P（CBMADMAEMA）上。此外，负载DOX的ZnO@P（CBMADMAEMA）在被肿瘤细胞内吞后可实现溶酶体酸性降解并释放DOX，从而实现癌症的协同治疗，这归因于锌和DOX的抗癌作用的结合。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb2e/6401959/2d8e21c9d146/polymers-10-01272-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb2e/6401959/a46a4e3f15bc/polymers-10-01272-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb2e/6401959/fb996a4ec29c/polymers-10-01272-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb2e/6401959/c4446653fe96/polymers-10-01272-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb2e/6401959/4774f750da2d/polymers-10-01272-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb2e/6401959/26be459acccc/polymers-10-01272-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb2e/6401959/abbb8c77961d/polymers-10-01272-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb2e/6401959/b999891e316e/polymers-10-01272-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb2e/6401959/6e62f369fa06/polymers-10-01272-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb2e/6401959/2d8e21c9d146/polymers-10-01272-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb2e/6401959/a46a4e3f15bc/polymers-10-01272-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb2e/6401959/fb996a4ec29c/polymers-10-01272-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb2e/6401959/c4446653fe96/polymers-10-01272-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb2e/6401959/4774f750da2d/polymers-10-01272-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb2e/6401959/26be459acccc/polymers-10-01272-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb2e/6401959/abbb8c77961d/polymers-10-01272-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb2e/6401959/b999891e316e/polymers-10-01272-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb2e/6401959/6e62f369fa06/polymers-10-01272-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb2e/6401959/2d8e21c9d146/polymers-10-01272-g008.jpg

相似文献

[1]
ZnO Quantum Dots Modified by pH-Activated Charge-Reversal Polymer for Tumor Targeted Drug Delivery.

Polymers (Basel). 2018-11-15

[2]
pH-Sensitive ZnO Quantum Dots-Doxorubicin Nanoparticles for Lung Cancer Targeted Drug Delivery.

ACS Appl Mater Interfaces. 2016-8-19

[3]
Tuning of surface protein adsorption by spherical mixed charged silica brushes (MCB) with zwitterionic carboxybetaine component.

J Mater Chem B. 2017-1-21

[4]
Triple stimuli-responsive ZnO quantum dots-conjugated hollow mesoporous carbon nanoplatform for NIR-induced dual model antitumor therapy.

J Colloid Interface Sci. 2019-9-30

[5]
Detachable Polyzwitterion-Coated Ternary Nanoparticles Based on Peptide Dendritic Carbon Dots for Efficient Drug Delivery in Cancer Therapy.

ACS Appl Mater Interfaces. 2018-12-5

[6]
Development of zwitterionic polymer-based doxorubicin conjugates: tuning the surface charge to prolong the circulation and reduce toxicity.

Langmuir. 2014-4-8

[7]
Synergistic dual-pH responsive copolymer micelles for pH-dependent drug release.

Nanoscale. 2016-1-21

[8]
Multifunctional Mesoporous Silica Nanoparticles Based on Charge-Reversal Plug-Gate Nanovalves and Acid-Decomposable ZnO Quantum Dots for Intracellular Drug Delivery.

ACS Appl Mater Interfaces. 2015-12-9

[9]
Tumor-targeting and imaging micelles for pH-triggered anticancer drug release and combined photodynamic therapy.

J Biomater Sci Polym Ed. 2020-8

[10]
pH-sensitive tangeretin-ZnO quantum dots exert apoptotic and anti-metastatic effects in metastatic lung cancer cell line.

Mater Sci Eng C Mater Biol Appl. 2018-7-2

引用本文的文献

[1]
In-depth investigation the size effect of zinc oxide nanostructures on the photodegradation of different dyes under UV-irradiation: anticancer application.

Sci Rep. 2025-8-28

[2]
A systematic review of nanocarriers used in medicine and beyond - definition and categorization framework.

J Nanobiotechnology. 2025-2-7

[3]
Quantum Dots in Cancer Theranostics: A Thorough Review of Recent Advancements in Bioimaging, Tracking, and Therapy Across Various Cancer Types.

Curr Pharm Biotechnol. 2025

[4]
Recent Breakthroughs in Using Quantum Dots for Cancer Imaging and Drug Delivery Purposes.

Nanomaterials (Basel). 2023-9-15

[5]
RAFT Hydroxylated Polymers as Templates and Ligands for the Synthesis of Fluorescent ZnO Quantum Dots.

Nanomaterials (Basel). 2022-10-1

[6]
Synthesis and Characterization of Polyvinylpyrrolidone-Modified ZnO Quantum Dots and Their In Vitro Photodynamic Tumor Suppressive Action.

Int J Mol Sci. 2021-7-28

[7]
Fluorescent quantum dots: An insight on synthesis and potential biological application as drug carrier in cancer.

Biochem Biophys Rep. 2021-3-14

[8]
Synthesis and performance of ZnO quantum dots water-based fluorescent ink for anti-counterfeiting applications.

Sci Rep. 2021-3-12

[9]
Novel zwitterionic vectors: Multi-functional delivery systems for therapeutic genes and drugs.

Comput Struct Biotechnol J. 2020-7-25

[10]
Gene Expression Profiling of the Liver and Lung in Mice After Exposure to ZnO Quantum Dots.

Int J Nanomedicine. 2020-4-28

本文引用的文献

[1]
Protein Resistant Polymeric Biomaterials.

ACS Macro Lett. 2017-9-19

[2]
pH-Sensitive Zwitterionic Polymer as an Antimicrobial Agent with Effective Bacterial Targeting.

ACS Biomater Sci Eng. 2018-1-8

[3]
pH- and redox-triggered synergistic controlled release of a ZnO-gated hollow mesoporous silica drug delivery system.

J Mater Chem B. 2015-2-21

[4]
ZnO quantum dots modified bioactive glass nanoparticles with pH-sensitive release of Zn ions, fluorescence, antibacterial and osteogenic properties.

J Mater Chem B. 2016-12-28

[5]
Tuning of surface protein adsorption by spherical mixed charged silica brushes (MCB) with zwitterionic carboxybetaine component.

J Mater Chem B. 2017-1-21

[6]
Stimuli-Responsive Microgels and Microgel-Based Systems: Advances in the Exploitation of Microgel Colloidal Properties and Their Interfacial Activity.

Polymers (Basel). 2018-4-9

[7]
Fabrication of Photothermo-Responsive Drug-Loaded Nanogel for Synergetic Cancer Therapy.

Polymers (Basel). 2018-10-4

[8]
Zwitterionic Nanocages Overcome the Efficacy Loss of Biologic Drugs.

Adv Mater. 2018-2-19

[9]
Tumor target amplification: Implications for nano drug delivery systems.

J Control Release. 2018-2-16

[10]
Surface-adaptive zwitterionic nanoparticles for prolonged blood circulation time and enhanced cellular uptake in tumor cells.

Acta Biomater. 2017-10-25

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

推荐工具

医学文档翻译智能文献检索