Hamidu Aisha, Pitt William G, Husseini Ghaleb A
Biomedical Engineering Program, College of Engineering, American University of Sharjah, Sharjah P.O. Box 26666, United Arab Emirates.
Department of Chemical Engineering, Brigham Young University, Provo, UT 84602, USA.
Nanomaterials (Basel). 2023 Sep 15;13(18):2566. doi: 10.3390/nano13182566.
Cancer is one of the leading causes of death worldwide. Because each person's cancer may be unique, diagnosing and treating cancer is challenging. Advances in nanomedicine have made it possible to detect tumors and quickly investigate tumor cells at a cellular level in contrast to prior diagnostic techniques. Quantum dots (QDs) are functional nanoparticles reported to be useful for diagnosis. QDs are semiconducting tiny nanocrystals, 2-10 nm in diameter, with exceptional and useful optoelectronic properties that can be tailored to sensitively report on their environment. This review highlights these exceptional semiconducting QDs and their properties and synthesis methods when used in cancer diagnostics. The conjugation of reporting or binding molecules to the QD surface is discussed. This review summarizes the most recent advances in using QDs for in vitro imaging, in vivo imaging, and targeted drug delivery platforms in cancer applications.
癌症是全球主要死因之一。由于每个人的癌症可能都是独特的,因此癌症的诊断和治疗具有挑战性。与先前的诊断技术相比,纳米医学的进步使得在细胞水平上检测肿瘤并快速研究肿瘤细胞成为可能。量子点(QDs)是据报道可用于诊断的功能性纳米颗粒。量子点是直径为2-10纳米的半导体微小纳米晶体,具有特殊且有用的光电特性,可进行定制以灵敏地报告其周围环境。本综述重点介绍了这些特殊的半导体量子点及其在癌症诊断中的特性和合成方法。还讨论了报告分子或结合分子与量子点表面的缀合。本综述总结了在癌症应用中使用量子点进行体外成像、体内成像和靶向药物递送平台的最新进展。