Chang Ray, Tsai Wei-Bor
Department of Chemical Engineering, National Taiwan University, Taipei 10617, Taiwan.
Advanced Research Center for Green Materials Science and Technology, National Taiwan University, Taipei 10617, Taiwan.
Polymers (Basel). 2018 Oct 4;10(10):1098. doi: 10.3390/polym10101098.
Temperature stimulus, easy modulation in comparison to other environmental stimuli, makes thermo-responsive nanocarriers popular in the applications of controlled drug release for cancer therapy. In this study, photosensitive sodium copper chlorophyllin (SCC) was incorporated into thermo-responsive polymeric nanogels consisted of -isopropylacrylamide and -(hydroxymethyl)acrylamide. Significant heat was generated from the SCC-containing nanogels under the exposure to 532-nm green laser, and resulted in cell mortality. The thermo-responsive nanogel loaded with 5-FU, an anti-cancer drug, released the drug explosively when exposed to green laser. The combination of hyperthermia and temperature-induced drug release via green laser irradiation greatly enhanced cell mortality to a maximal extent. Such photothermo-responsive nanogel possesses a great potential in anti-cancer treatment.
与其他环境刺激相比，温度刺激易于调节，这使得热响应性纳米载体在癌症治疗的控释药物应用中很受欢迎。在本研究中，将光敏叶绿素铜钠（SCC）掺入由N-异丙基丙烯酰胺和N-（羟甲基）丙烯酰胺组成的热响应性聚合物纳米凝胶中。含SCC的纳米凝胶在暴露于532nm绿色激光下会产生大量热量，并导致细胞死亡。负载抗癌药物5-氟尿嘧啶（5-FU）的热响应性纳米凝胶在暴露于绿色激光时会爆炸性地释放药物。通过绿色激光照射进行的热疗和温度诱导的药物释放相结合，极大地提高了细胞死亡率。这种光热响应性纳米凝胶在抗癌治疗中具有巨大潜力。
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