Tandale P, Choudhary Neeraj, Singh Joga, Sharma Akanksha, Shukla Ananya, Sriram Pavani, Soni Udit, Singla Neha, Barnwal Ravi P, Singh Gurpal, Kaur Indu Pal, Suttee Ashish
School of Pharmaceutical Sciences, Lovely Professional University, Punjab, India.
Univesity Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India.
Biochem Biophys Rep. 2021 Mar 14;26:100962. doi: 10.1016/j.bbrep.2021.100962. eCollection 2021 Jul.
Quantum dots (QDs) are nanocrystals of semiconducting material possessing quantum mechanical characteristics with capability to get conjugated with drug moieties. The particle size of QDs varies from 2 to 10 nm and can radiate a wide range of colours depending upon their size. Their wide and diverse usage of QDs across the world is due to their adaptable properties like large quantum yield, photostability, and adjustable emission spectrum. QDs are nanomaterials with inherent electrical characteristics that can be used as drug carrier vehicle and as a diagnostic in the field of nanomedicine. Scientists from various fields are aggressively working for the development of single platform that can sense, can produce a microscopic image and even be used to deliver a therapeutic agent. QDs are the fluorescent nano dots with which the possibilities of the drug delivery to a targeted site and its biomedical imaging can be explored. This review is mainly focused on the different process of synthesis of QDs, their application especially in the areas of malignancies and as a theranostic tool. The attempt is to consolidate the data available for the use of QDs in the biomedical applications.
量子点（QDs）是具有量子力学特性的半导体材料纳米晶体，能够与药物部分结合。量子点的粒径在2到10纳米之间，根据其大小可发出多种颜色。量子点在全球范围内得到广泛多样的应用，这归因于它们具有诸如高量子产率、光稳定性和可调节发射光谱等适应性特性。量子点是具有固有电学特性的纳米材料，可作为药物载体和纳米医学领域的诊断工具。来自各个领域的科学家们正在积极致力于开发一种单一平台，该平台能够进行传感、生成微观图像甚至用于递送治疗剂。量子点是荧光纳米点，借助它们可以探索药物靶向递送及其生物医学成像的可能性。本综述主要关注量子点的不同合成过程、它们的应用，特别是在恶性肿瘤领域的应用以及作为一种诊疗工具的应用。目的是整合可用于量子点在生物医学应用中的数据。
