a Department of Epidemiology and Health Statistics , School of Public Health, Anhui Medical University , Hefei , Anhui , China.
b Anhui Province Key Laboratory of Major Autoimmune Disease, Anhui Medical University , Hefei , Anhui , China.
Immunol Invest. 2019 Jul;48(5):505-520. doi: 10.1080/08820139.2019.1567534. Epub 2019 Apr 8.
: To identify accurate occurrence and risk of cardiovascular (CV) events (stroke and myocardial infarction [MI]) in patients with systemic lupus erythematosus (SLE). : Systemic literature search in PubMed and additional manual search were performed to obtain interested studies until March 31, 2018. The pooled incidences and risk of stroke and MI were calculated. : A total of 24 studies were included in this meta-analysis. For MI, a total of 1,516 SLE patients were reported to had MI (n = 96,154) over a mean follow-up of 9.98 years: incidence 2.0% (95% CI: 1.7-2.4%), i.e. 0.20/100 pyrs; in the five studies, 360 SLE patients (n = 18,943) and 817 controls had MI (n = 111,525), revealing that the risk of MI in SLE population was 3.04 times higher than in the general population (RR = 3.04, 95% CI: 1.81-5.11). For stroke, the incidence of 17 studies during the 10.09 follow-up period using random model was 4.4% (95% CI: 3.6-5.1%), i.e. 0.44/100 pyrs; in the 7 studies, 694 SLE patients (n = 22,594) and 4,034 controls had stroke (n = 255,023), indicating that the risk of MI in SLE population was 1.95 times higher than that in the general population (RR = 1.95, 95% CI: 1.52-2.53). : Based on the findings from previous reports, our meta-analysis showed that patients with SLE have been at higher risk of CV events.
: 目的：明确系统性红斑狼疮（SLE）患者发生心血管（CV）事件（中风和心肌梗死[MI]）的准确发生率和风险。 : 对 PubMed 中的系统文献进行检索，并进行额外的手动搜索，以获取截至 2018 年 3 月 31 日的相关研究。计算中风和 MI 的合并发生率和风险。 : 共有 24 项研究纳入本荟萃分析。对于 MI，共有 1516 例 SLE 患者报告在平均 9.98 年的随访中有 MI（n=96154）：发生率为 2.0%（95%CI：1.7-2.4%），即 0.20/100 人年；在五项研究中，360 例 SLE 患者（n=18943）和 817 名对照者发生了 MI（n=111525），表明 SLE 人群的 MI 风险比一般人群高 3.04 倍（RR=3.04，95%CI：1.81-5.11）。对于中风，采用随机模型的 17 项研究在 10.09 年的随访期间的发生率为 4.4%（95%CI：3.6-5.1%），即 0.44/100 人年；在 7 项研究中，694 例 SLE 患者（n=22594）和 4034 名对照者发生了中风（n=255023），表明 SLE 人群的中风风险比一般人群高 1.95 倍（RR=1.95，95%CI：1.52-2.53）。 : 基于之前报告的结果，我们的荟萃分析表明，SLE 患者发生 CV 事件的风险较高。
