重新审视量子点的细胞毒性：深入概述。
Revisiting the cytotoxicity of quantum dots: an in-depth overview.
作者信息
Nikazar Sohrab, Sivasankarapillai Vishnu Sankar, Rahdar Abbas, Gasmi Salim, Anumol P S, Shanavas Muhammad Salman
机构信息
Chemical Engineering Faculty, Engineering College, University of Tehran, P.O. Box 14155-6455, Tehran, Iran.
Department of Chemistry, NSS Hindu College, Changanacherry, Kerala, 686102, India.
出版信息
Biophys Rev. 2020 Jun;12(3):703-718. doi: 10.1007/s12551-020-00653-0. Epub 2020 Mar 5.
Abstract
Recently, medical research has been shifting its focus to nanomedicine and nanotherapeutics in the pursuit of drug development research. Quantum dots (QDs) are a critical class of nanomaterials due to their unique properties, which include optical, electronic, and engineered biocompatibility in physiological environments. These properties have made QDs an attractive biomedical resource such that they have found application as both in vitro labeling and in vivo theranostic (therapy-diagnostic) agents. Considerable research has been conducted exploring the suitability of QDs in theranostic applications, but the cytotoxicity of QDs remains an obstacle. Several types of QDs have been investigated over the past decades, which may be suitable for use in biomedical applications if the barrier of cytotoxicity can be resolved. This review attempts to report and analyze the cytotoxicity of the major QDs along with relevant related aspects.
摘要
最近，医学研究在药物研发研究中一直将重点转向纳米医学和纳米治疗学。量子点（QDs）因其独特的性质而成为一类关键的纳米材料，这些性质包括光学、电子性质以及在生理环境中的工程化生物相容性。这些特性使量子点成为一种有吸引力的生物医学资源，以至于它们已被用作体外标记和体内治疗诊断（治疗 - 诊断）试剂。已经进行了大量研究来探索量子点在治疗诊断应用中的适用性，但量子点的细胞毒性仍然是一个障碍。在过去几十年中已经研究了几种类型的量子点，如果细胞毒性障碍能够得到解决，它们可能适用于生物医学应用。本综述试图报告和分析主要量子点的细胞毒性以及相关方面。
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