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妊娠使狼变温顺。

When pregnancy tames the wolf.

机构信息

Departments of Medicine and Pathology, Colton Center for Autoimmunity, New York University School of Medicine, New York, NY

Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, New York University School of Medicine, New York, NY.

出版信息

J Exp Med. 2019 May 6;216(5):1012-1013. doi: 10.1084/jem.20190378. Epub 2019 Apr 8.

DOI:10.1084/jem.20190378
PMID:30962247
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6504221/
Abstract

A state of relative immunosuppression exists in normal pregnancy. In this issue of , Hong et al. (https://doi.org/10.1084/jem.20190185) perform blood immunomonitoring in pregnancy, in both healthy women and women with lupus, and observe early and sustained transcriptional modulation of lupus-related pathways in both groups. When signatures of inflammation did not normalize in lupus, risk of pregnancy complications was increased.

摘要

正常妊娠时存在相对免疫抑制状态。在本期《 》中，Hong 等人（https://doi.org/10.1084/jem.20190185）对健康孕妇和狼疮孕妇进行了血液免疫监测，观察到两组均存在早期且持续的狼疮相关通路转录调节。当狼疮患者的炎症特征未恢复正常时，妊娠并发症的风险增加。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea62/6504221/651689be337d/JEM_20190378_Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea62/6504221/651689be337d/JEM_20190378_Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea62/6504221/651689be337d/JEM_20190378_Fig1.jpg

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引用本文的文献

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本文引用的文献

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Clin Transplant. 2018 Dec;32(12):e13429. doi: 10.1111/ctr.13429. Epub 2018 Nov 18.
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Type I interferon in rheumatic diseases.I 型干扰素在风湿性疾病中的作用。
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Predictors of Pregnancy Outcomes in Patients With Lupus: A Cohort Study.
狼疮患者妊娠结局的预测因素：一项队列研究。
Ann Intern Med. 2015 Aug 4;163(3):153-63. doi: 10.7326/M14-2235.
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