Han Gong-Hai, Peng Jiang, Liu Ping, Ding Xiao, Wei Shuai, Lu Sheng, Wang Yu
Kunming Medical University, Kunming, Yunnan Province; Institute of Orthopedics, Chinese PLA General Hospital, Beijing, China.
Institute of Orthopedics, Chinese PLA General Hospital, Beijing, China.
Neural Regen Res. 2019 Aug;14(8):1343-1351. doi: 10.4103/1673-5374.253511.
In recent years, the use of Schwann cell transplantation to repair peripheral nerve injury has attracted much attention. Animal-based studies show that the transplantation of Schwann cells in combination with nerve scaffolds promotes the repair of injured peripheral nerves. Autologous Schwann cell transplantation in humans has been reported recently. This article reviews current methods for removing the extracellular matrix and analyzes its composition and function. The development and secretory products of Schwann cells are also reviewed. The methods for the repair of peripheral nerve injuries that use myelin and Schwann cell transplantation are assessed. This survey of the literature data shows that using a decellularized nerve conduit combined with Schwann cells represents an effective strategy for the treatment of peripheral nerve injury. This analysis provides a comprehensive basis on which to make clinical decisions for the repair of peripheral nerve injury.
近年来，施万细胞移植用于修复周围神经损伤备受关注。基于动物的研究表明，施万细胞与神经支架联合移植可促进受损周围神经的修复。最近已有关于人类自体施万细胞移植的报道。本文综述了当前去除细胞外基质的方法，并分析了其组成和功能。还综述了施万细胞的发育及分泌产物。评估了使用髓磷脂和施万细胞移植修复周围神经损伤的方法。对文献数据的这项调查表明，使用去细胞神经导管联合施万细胞是治疗周围神经损伤的一种有效策略。该分析为周围神经损伤修复的临床决策提供了全面依据。
