College of Materials Science and Engineering, Shandong University of Science and Technology, Qingdao 266590, China.
College of Materials Science and Engineering, Shandong University of Science and Technology, Qingdao 266590, China.
J Colloid Interface Sci. 2019 Jul 1;547:309-317. doi: 10.1016/j.jcis.2019.04.017. Epub 2019 Apr 5.
Magnesium (Mg) alloys have received considerable attentions as the emerging biodegradable implant materials in orthopedic surgery applications. However, the rapid corrosion rate and the susceptibility to bacterial infection have prevented their wide spread applications to date. In this work, the gentamicin-loaded multilayers have been constructed on Mg alloys through spin-assisted layer-by-layer (SLbL) assembly. Heat treatment is applied for improving the corrosion resistance and prolonging the drug release profile. In addition, the treated multilayer can promote the formation of hydroxyapatite (HA) during the long-time immersion in Hank's balanced salt solution (HBSS).
镁（Mg）合金作为新兴的可生物降解植入材料，在骨科手术应用中受到了广泛关注。然而，其快速的腐蚀速率和易受细菌感染的特性，限制了其广泛应用。在这项工作中，通过旋转辅助层层自组装（SLbL）技术，将庆大霉素负载的多层膜构建在镁合金上。通过热处理来提高耐腐蚀性并延长药物释放曲线。此外，经过处理的多层膜在长时间浸泡于 Hank 的平衡盐溶液（HBSS）中时，可以促进羟基磷灰石（HA）的形成。
