Al-Jumaili Ahmed, Kumar Avishek, Bazaka Kateryna, Jacob Mohan V
Electronics Materials Lab, College of Science and Engineering, James Cook University, Townsville, QLD 4811, Australia.
Physics Department, College of Science, Ramadi, Anbar University, Ramadi 11, Iraq.
Polymers (Basel). 2018 May 10;10(5):515. doi: 10.3390/polym10050515.
The persistent issue of bacterial and fungal colonization of artificial implantable materials and the decreasing efficacy of conventional systemic antibiotics used to treat implant-associated infections has led to the development of a wide range of antifouling and antibacterial strategies. This article reviews one such strategy where inherently biologically active renewable resources, i.e., plant secondary metabolites (PSMs) and their naturally occurring combinations (i.e., essential oils) are used for surface functionalization and synthesis of polymer thin films. With a distinct mode of antibacterial activity, broad spectrum of action, and diversity of available chemistries, plant secondary metabolites present an attractive alternative to conventional antibiotics. However, their conversion from liquid to solid phase without a significant loss of activity is not trivial. Using selected examples, this article shows how plasma techniques provide a sufficiently flexible and chemically reactive environment to enable the synthesis of biologically-active polymer coatings from volatile renewable resources.
人工可植入材料上细菌和真菌定植的长期问题，以及用于治疗植入相关感染的传统全身性抗生素疗效的降低，导致了多种防污和抗菌策略的发展。本文综述了一种这样的策略，即利用具有内在生物活性的可再生资源，即植物次生代谢产物（PSMs）及其天然存在的组合（即精油）进行表面功能化和聚合物薄膜的合成。植物次生代谢产物具有独特的抗菌活性模式、广泛的作用谱和多样的可用化学性质，是传统抗生素的一种有吸引力的替代品。然而，将它们从液相转化为固相而不显著损失活性并非易事。本文通过选定的例子展示了等离子体技术如何提供一个足够灵活且化学反应性强的环境，以实现由挥发性可再生资源合成生物活性聚合物涂层。
