鉴定与耐受相关的生物标志物。
Identification of Biomarkers Associated with Tolerance.
机构信息
Department of Chemistry, Tshwane University of Technology, P.O. Box 680, Pretoria 0001, South Africa.
Department of Biotechnology and Food Technology, Tshwane University of Technology, P.O. Box 680, Pretoria 0001, South Africa.
出版信息
Molecules. 2024 Jul 29;29(15):3582. doi: 10.3390/molecules29153582.
Citrus black spot (CBS) is a fungal disease caused by Kiely, (McAlpine Van der Aa), with most cultivars being susceptible to infection. Currently, disease control is based on the application of protective fungicides, which is restricted due to resistance, health and environmental concerns. Although using natural products for disease management is gaining momentum, more advances are required. This study obtained the metabolic profiles of the essential oil and cuticular waxes of two citrus cultivars with a varying susceptibility to CBS infection using gas chromatography-mass spectrometry. A multivariate data analysis identified possible biomarker compounds that contributed to the difference in susceptibility between the two cultivars. Several identified biomarkers were tested in vitro for their antifungal properties against . Two biomarkers, propanoic acid and linalool, were able to completely inhibit pathogen growth at 750 mg/L and 2000 mg/L, respectively.
柑橘黑斑病（CBS）是一种由 Kiely（McAlpine Van der Aa）引起的真菌病，大多数品种易受感染。目前，疾病控制基于保护性杀真菌剂的应用，由于抗性、健康和环境问题，这种方法受到限制。尽管利用天然产物进行疾病管理的趋势正在增强，但仍需要更多的进展。本研究使用气相色谱-质谱法获得了对 CBS 感染具有不同易感性的两种柑橘品种的精油和角质层蜡的代谢谱。多元数据分析确定了可能导致两个品种易感性差异的生物标志物化合物。对几种鉴定出的生物标志物进行了体外抗真菌活性测试。两种生物标志物，丙酸和芳樟醇，分别在 750mg/L 和 2000mg/L 时能够完全抑制病原菌的生长。
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