Rosemberg E, Jewelewicz R, Shortle B E
Fertil Steril. 1986 Nov;46(5):865-9. doi: 10.1016/s0015-0282(16)49826-2.
Further demonstration of the ability of the hybrid human chorionic gonadotropin (hCG) compound, AB1ER-CR-2XY, to induce ovulation is presented. Nineteen patients previously treated with human menopausal gonadotropin (hMG) and commercial hCG were selected for the study. The patients received 37 courses of treatment with dosages of hMG ranging from 1200 IU (16 ampules) to 8400 IU (112 ampules), followed by the administration of 5000 or 10,000 IU of the hybrid hCG. Of the total number of courses given, 75.5% were ovulatory; serum progesterone levels at midluteal phase of the cycle were within normal range, and the cycle length was about 12 days. Seven patients became pregnant, three with twins, one with triplets, and three with aborted single fetuses. Before the hybrid hCG was administered the serum estrogen levels were less than 1200 pg/ml in 12 cycles (32.4%), and the estrogen levels ranged from 1400 to 7400 pg/ml in 25 (67.6%). However, in spite of high estrogen levels, clinical hyperstimulation, which occurred in 22.4% of previous treatments with conventional hMG-commercial hCG, did not develop when the hybrid hCG was administered, an effect which could be attributed to its short circulatory half-life. Studies are in progress to confirm whether the hybrid hCG may provide a better margin of safety than commercial hCG for ovulation induction in patients pretreated with hMG.
本文进一步展示了人绒毛膜促性腺激素（hCG）复合剂AB1ER-CR-2XY诱导排卵的能力。本研究选取了19名先前接受过人绝经期促性腺激素（hMG）和市售hCG治疗的患者。患者接受了37个疗程的治疗，hMG剂量范围为1200国际单位（16安瓿）至8400国际单位（112安瓿），随后给予5000或10000国际单位的复合hCG。在所有给予的疗程中，75.5%出现排卵；月经周期黄体中期的血清孕酮水平在正常范围内，周期长度约为12天。7名患者怀孕，3名怀双胞胎，1名怀三胞胎，3名出现单胎流产。在给予复合hCG之前，12个周期（32.4%）的血清雌激素水平低于1200皮克/毫升，25个周期（67.6%）的雌激素水平在1400至7400皮克/毫升之间。然而，尽管雌激素水平较高，但在给予复合hCG时，并未出现临床过度刺激，而在先前使用传统hMG-市售hCG治疗时，22.4%的患者出现过这种情况，这一效果可能归因于其较短的循环半衰期。目前正在进行研究，以确认复合hCG在对接受hMG预处理的患者进行排卵诱导时，是否比市售hCG具有更好的安全边际。
