Wang Enbo, Han Jianmin, Zhang Xuehui, Wu Yuhan, Deng Xu-Liang
Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, 22 Zhongguancun South Street, Haidian District, Beijing, China.
Department of Dental Materials, Peking University School and Hospital of Stomatology, 22 Zhongguancun South Street, Haidian District, Beijing, China.
Regen Biomater. 2019 Mar;6(2):107-111. doi: 10.1093/rb/rby029. Epub 2019 Mar 21.
The mechanism of the mineralization process induced by natural mineralized collagen (MC) has been investigated for decades. The purpose of this study was to investigate the efficacy of self-assembled MC for peri-implant bone defect reconstruction in a mini pig. A standardized peri-implant bone defect model was created using 14 mini pig mandibles. Two materials were evaluated, i.e. a mixture of hydroxyapatite and collagen (Type A, TA), and self-assembled MC (Type B, TB). Bio-Oss (BO) and untreated (blank control, BC) groups were used as controls. After 3- and 6-month healing periods, the mini pigs were sacrificed for histomorphometric and microcomputed tomography analysis. After 3 months of healing, the average alveolar ridge height was 3.27 ± 1.57 mm for group TA, 3.28 ± 2.02 mm for group TB and 3.37 ± 1.09 mm for group BO, while group BC showed the lowest height of 2.68 ± 0.47 mm. After 6 months of healing, the average alveolar ridge height was 2.64 ± 1.13 mm for group TA, 4.31 ± 1.80 mm for group TB and 3.87 ± 1.38 mm for group BO, while group BC showed the lowest height of 2.48 ± 1.80 mm. The experimental groups and control group showed similar bone volume density, bone complexity and histological reaction. The self-assembled MC (Type B) stimulated new bone formation in the reconstruction of deficient alveolar ridges around the dental implant; it also displayed excellent clinical operability compared with bone grafts without collagen.
天然矿化胶原（MC）诱导矿化过程的机制已被研究了数十年。本研究的目的是探讨自组装MC用于小型猪种植体周围骨缺损重建的效果。使用14个小型猪下颌骨创建了标准化的种植体周围骨缺损模型。评估了两种材料，即羟基磷灰石和胶原的混合物（A型，TA）以及自组装MC（B型，TB）。生物骨（BO）组和未处理组（空白对照，BC）用作对照。在3个月和6个月的愈合期后，处死小型猪进行组织形态计量学和微型计算机断层扫描分析。愈合3个月后，TA组的平均牙槽嵴高度为3.27±1.57mm，TB组为3.28±2.02mm，BO组为3.37±1.09mm，而BC组的高度最低，为2.68±0.47mm。愈合6个月后，TA组的平均牙槽嵴高度为2.64±1.13mm，TB组为4.31±1.80mm，BO组为3.87±1.38mm，而BC组的高度最低，为2.48±1.80mm。实验组和对照组在骨体积密度、骨复杂性和组织学反应方面相似。自组装MC（B型）在牙种植体周围牙槽嵴缺损重建中刺激了新骨形成；与不含胶原的骨移植材料相比，它还表现出优异的临床可操作性。
