放疗后伴肺转移的多形性腺瘤恶变型下颌下腺癌的有效化疗：1例报告
Effective chemotherapy for submandibular gland carcinoma ex pleomorphic adenoma with lung metastasis after radiotherapy: A case report.
作者信息
Chen Zhi-Yuan, Zhang Yu, Tu Yan, Zhao Wei, Li Mei
机构信息
Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China.
Oncology Department, the Second People's Hospital of Yunnan Province, Kunming 650000, Yunan Province, China.
出版信息
World J Clin Cases. 2019 Mar 26;7(6):792-797. doi: 10.12998/wjcc.v7.i6.792.
BACKGROUND
Only a few cases of carcinoma ex pleomorphic adenoma arising in the submandibular gland have ever been reported, all with a poor prognosis. The standard treatment for salivary gland carcinoma ex pleomorphic adenoma is surgical resection combined with postoperative radiotherapy, but the necessity of chemotherapy as well as the most appropriate treatment regimen for patients with distant metastasis after radiotherapy remains controversial.
CASE SUMMARY
This report presents the case of a 73-year-old woman who suffered submandibular gland carcinoma ex pleomorphic adenoma. She accepted surgery to remove the mass; she was found to have lung metastasis after radiotherapy. Her condition was controlled by chemotherapy with liposomal doxorubicin plus cisplatin.
CONCLUSION
The positive clinical outcome in the patient reveals that this chemotherapy regimen may be an alternative treatment for such a condition.
背景
下颌下腺多形性腺瘤癌变的病例报道较少，且预后均较差。涎腺多形性腺瘤癌变的标准治疗方法是手术切除联合术后放疗，但对于化疗的必要性以及放疗后发生远处转移患者的最佳治疗方案仍存在争议。
病例摘要
本报告介绍了一名73岁患下颌下腺多形性腺瘤癌变的女性患者。她接受了肿物切除术；放疗后发现有肺转移。她通过脂质体阿霉素联合顺铂化疗控制了病情。
结论
该患者的良好临床结果表明，这种化疗方案可能是治疗此类疾病的一种替代疗法。
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