Li Yujun, Yang Qi, Yang Liquan, Lei Ning, Zheng Ke
Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, P. R. China.
Chem Commun (Camb). 2019 Apr 23;55(34):4981-4984. doi: 10.1039/c9cc01378d.
A practical, scalable electrochemical dehydrogenative cross-coupling of P(O)H compounds with thiols, phenols and alcohols in both an undivided cell and a continuous-flow setup is disclosed. Its broad substrate scope (>50 examples), good functional-group tolerance and scalability (>10 g) show potential for practical synthesis. A preliminary mechanistic study suggests that the phosphorus radicals are involved in the catalytic cycle.
本文公开了一种在无隔膜电池和连续流动装置中，实现磷氢化合物与硫醇、酚类和醇类进行实用、可扩展的电化学脱氢交叉偶联反应。其广泛的底物范围（>50个实例）、良好的官能团耐受性和可扩展性（>10 g）显示出在实际合成中的潜力。初步机理研究表明，磷自由基参与了催化循环。
