大肠杆菌中碱性细胞内pH对SOS功能的诱导作用。
Induction of SOS functions by alkaline intracellular pH in Escherichia coli.
作者信息
Schuldiner S, Agmon V, Brandsma J, Cohen A, Friedman E, Padan E
出版信息
J Bacteriol. 1986 Nov;168(2):936-9. doi: 10.1128/jb.168.2.936-939.1986.
Abstract
Alkalinization of intracellular pH (pHi) causes an increase in UV resistance in wild-type and pH-sensitive mutant (DZ3) cells of Escherichia coli. Utilizing cells transformed with a plasmid (pA7) which bears the uvrA promoter fused to galK galactokinase structural gene, it was shown that alkaline pHi leads to an increase in the specific activity of galactokinase. This effect was not displayed in a mutant bearing a recA-insensitive lexA gene, nor in cells harboring a plasmid (pA8) in which the galK is fused to a lexA-insensitive uvrA promoter. Hence, the effects of pHi on cells functions may involve the lexA product of the SOS system.
摘要
细胞内pH值（pHi）的碱化会导致大肠杆菌野生型和pH敏感突变体（DZ3）细胞的紫外线抗性增加。利用用携带与galK半乳糖激酶结构基因融合的uvrA启动子的质粒（pA7）转化的细胞，结果表明碱性pHi会导致半乳糖激酶的比活性增加。在携带recA不敏感lexA基因的突变体中，以及在含有galK与lexA不敏感uvrA启动子融合的质粒（pA8）的细胞中，均未显示出这种效应。因此，pHi对细胞功能的影响可能涉及SOS系统的lexA产物。
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