Maller R, Frydén A, Sörén L
Acta Pathol Microbiol Scand C. 1978 Jun;86C(3):93-8. doi: 10.1111/j.1699-0463.1978.tb02564.x.
The phytohaemagglutinin (PHA) response of lymphocytes from seven patients with natural rubella infection was investigated during the acute, early and late convalescence stages of disease. When the lymphocytes were cultured in autologous serum, a moderate depression of the response, following stimulation with PHA in both optimal and suboptimal concentrations was obtained two weeks after the onset of exanthema (early convalescence). Two months later (late convalescence), the lymphocyte stimulation response had returned to almost normal values. On the other hand, lymphocytes incubated in pooled homologous serum reacted normally to PHA in optimal concentrations at all three stages. Determination of T- and B-lymphocytes did not reveal any change in the relative proportion of T-lymphocytes during the course of the disease. However, in late convalescence, a significant decrease in the relative number of B-lymphocytes was recorded.
对7例自然感染风疹患者在疾病的急性期、早期和晚期恢复期的淋巴细胞对植物血凝素（PHA）的反应进行了研究。当淋巴细胞在自体血清中培养时，皮疹出现两周后（早期恢复期），用最佳和次最佳浓度的PHA刺激后，反应出现中度抑制。两个月后（晚期恢复期），淋巴细胞刺激反应已恢复到几乎正常的值。另一方面，在汇集的同源血清中孵育的淋巴细胞在所有三个阶段对最佳浓度的PHA反应正常。T淋巴细胞和B淋巴细胞的测定未显示疾病过程中T淋巴细胞的相对比例有任何变化。然而，在晚期恢复期，记录到B淋巴细胞的相对数量显著减少。
