生长停滞特异性转录因子 5 在肿瘤发生过程中的作用：表达模式和基因组变异的最新研究进展。

Growth arrest specific transcript 5 in tumorigenesis process: An update on the expression pattern and genomic variants.

机构信息

Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

出版信息

Biomed Pharmacother. 2019 Apr;112:108723. doi: 10.1016/j.biopha.2019.108723. Epub 2019 Feb 27.

DOI:10.1016/j.biopha.2019.108723

PMID:30970522

Abstract

Growth arrest-specific 5 (GAS5) is a long non-coding RNA (lncRNA) with diverse functions in regulation of gene expression. Most studies have reported a role for this lncRNA in induction of cell apoptosis and suppression of tumorigenesis process. Although few studies demonstrated up-regulation of this lncRNA in tumor tissues compared to non-tumor tissues of the same origin, the results of in vitro functional studies mostly support the tumor suppressor role for GAS5. A number of recent studies have also shown associations between genomic variants of this gene and risk of cancer in some populations. The role of this lncRNA in modulation of response to anti-cancer regimens has been verified through both in vitro and clinical studies. Taken together, this lncRNA is a putative biomarker and therapeutic target in human malignancies.

摘要

生长停滞特异性基因 5（GAS5）是一种长链非编码 RNA（lncRNA），在基因表达调控方面具有多种功能。大多数研究报道了这种 lncRNA 在诱导细胞凋亡和抑制肿瘤发生过程中的作用。尽管少数研究表明与同一来源的非肿瘤组织相比，这种 lncRNA 在肿瘤组织中上调，但体外功能研究的结果大多支持 GAS5 的肿瘤抑制作用。最近的一些研究还表明，该基因的基因组变异与某些人群的癌症风险之间存在关联。通过体外和临床研究已经验证了这种 lncRNA 在调节抗癌方案反应中的作用。综上所述，这种 lncRNA 是人类恶性肿瘤的一个潜在的生物标志物和治疗靶点。