Osterberg E
Acta Psychiatr Scand. 1978 Oct;58(4):339-59. doi: 10.1111/j.1600-0447.1978.tb00240.x.
The coincidental occurrence of schizophrenia and rheumatoid arthritis is considered to be low in relation to the prevalence of the two diseases. In the present study, data from the patient statistics prepared by the Swedish Social Welfare Board were examined for the occurrence of rheumatic disease in schizophrenic patients. With the aid of the statistics and of questionnaires, 58 case-records were collected and studied. Very few cases were found of co-existing schizophrenia and inflammatory joint disease, rheumatoid arthritis in particular. There were, however, some cases of genuine schizophrenia and definite seropositive rheumatoid arthritis in the same patient. Rheumatoid arthritis is possibly uncommon also in combination with other psychiatric diseases that require hospital care. The ankylosing-spondylitis cases were over-represented in relation to the rheumatoid-arthritis cases included in the statistics from psychiatric care. Most of the 13 ankylosing-spondylitis patients whose case-records were studied had schizoaffective psychosis or atypical psychosis. The results of the investigation should be confirmed by epidemiological studies; this may contribute to the understanding of the aetiology of rheumatoid arthritis and of schizophrenia.
相较于这两种疾病的患病率，精神分裂症与类风湿性关节炎同时发生的情况被认为较为少见。在本研究中，对瑞典社会福利委员会编制的患者统计数据进行了检查，以了解精神分裂症患者中风湿性疾病的发生情况。借助这些统计数据和问卷，收集并研究了58份病例记录。发现同时患有精神分裂症和炎性关节病（尤其是类风湿性关节炎）的病例极少。然而，确实存在同一患者同时患有真性精神分裂症和确诊的血清阳性类风湿性关节炎的情况。类风湿性关节炎与其他需要住院治疗的精神疾病同时出现的情况可能也不常见。与精神科护理统计数据中纳入的类风湿性关节炎病例相比，强直性脊柱炎病例的占比过高。在研究的13例强直性脊柱炎患者中，大多数患有分裂情感性精神病或非典型精神病。本研究结果应通过流行病学研究加以证实；这可能有助于理解类风湿性关节炎和精神分裂症的病因。
