Wang Junli, Mei Jun, Ren Guodong
State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory for Biodiversity Science and Ecological Engineering, Institute of Plant Biology, School of Life Sciences, Fudan University, Shanghai, China.
Front Plant Sci. 2019 Mar 27;10:360. doi: 10.3389/fpls.2019.00360. eCollection 2019.
MicroRNAs (miRNAs), a class of endogenous, tiny, non-coding RNAs, are master regulators of gene expression among most eukaryotes. Intracellular miRNA abundance is regulated under multiple levels of control including transcription, processing, RNA modification, RNA-induced silencing complex (RISC) assembly, miRNA-target interaction, and turnover. In this review, we summarize our current understanding of the molecular components and mechanisms that influence miRNA biogenesis, homeostasis, and degradation in plants. We also make comparisons with findings from other organisms where necessary.
微小RNA（miRNA）是一类内源性的、微小的非编码RNA，是大多数真核生物中基因表达的主要调节因子。细胞内miRNA的丰度在多个控制水平下受到调节，包括转录、加工、RNA修饰、RNA诱导沉默复合体（RISC）组装、miRNA-靶标相互作用和周转。在这篇综述中，我们总结了目前对影响植物中miRNA生物合成、稳态和降解的分子成分及机制的理解。必要时，我们还会与其他生物体的研究结果进行比较。
