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本文引用的文献

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Long non-coding RNA SNHG20 promotes the tumorigenesis of oral squamous cell carcinoma via targeting miR-197/LIN28 axis.长链非编码 RNA SNHG20 通过靶向 miR-197/LIN28 轴促进口腔鳞状细胞癌的发生。
J Cell Mol Med. 2019 Jan;23(1):680-688. doi: 10.1111/jcmm.13987. Epub 2018 Nov 5.
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Long noncoding RNA FOXC2-AS1 facilitates the proliferation and progression of prostate cancer via targeting miR-1253/EZH2.长链非编码 RNA FOXC2-AS1 通过靶向 miR-1253/EZH2 促进前列腺癌的增殖和进展。
Gene. 2019 Feb 20;686:37-42. doi: 10.1016/j.gene.2018.10.085. Epub 2018 Oct 31.
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Tongmai Yangxin pills anti-oxidative stress alleviates cisplatin-induced cardiotoxicity: Network pharmacology analysis and experimental evidence.通脉养心丸抗氧化应激减轻顺铂致心肌毒性：网络药理学分析与实验证据。
Biomed Pharmacother. 2018 Dec;108:1081-1089. doi: 10.1016/j.biopha.2018.09.095. Epub 2018 Sep 28.
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HANR promotes hepatocellular carcinoma progression via miR-214/EZH2/TGF-β axis.HANR 通过 miR-214/EZH2/TGF-β 轴促进肝癌进展。
Biochem Biophys Res Commun. 2018 Nov 17;506(1):189-193. doi: 10.1016/j.bbrc.2018.10.038. Epub 2018 Oct 19.
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The suppression of ox-LDL-induced inflammatory cytokine release and apoptosis of HCAECs by long non-coding RNA-MALAT1 via regulating microRNA-155/SOCS1 pathway.长链非编码 RNA-MALAT1 通过调节 microRNA-155/SOCS1 通路抑制 ox-LDL 诱导的 HCAECs 炎症细胞因子释放和细胞凋亡。
Nutr Metab Cardiovasc Dis. 2018 Nov;28(11):1175-1187. doi: 10.1016/j.numecd.2018.06.017. Epub 2018 Jun 28.
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The long noncoding RNA SNHG1 regulates colorectal cancer cell growth through interactions with EZH2 and miR-154-5p.长链非编码 RNA SNHG1 通过与 EZH2 和 miR-154-5p 的相互作用调节结直肠癌细胞生长。
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Long noncoding RNA TCONS_00024652 regulates vascular endothelial cell proliferation and angiogenesis via microRNA-21.长链非编码RNA TCONS_00024652通过微小RNA-21调控血管内皮细胞增殖和血管生成。
Exp Ther Med. 2018 Oct;16(4):3309-3316. doi: 10.3892/etm.2018.6594. Epub 2018 Aug 10.

长链非编码RNA OIP5-AS1通过招募EZH2靶向糖原合成酶激酶-3β，加速氧化型低密度脂蛋白介导的血管内皮细胞凋亡。

Long noncoding RNA OIP5-AS1 accelerates the ox-LDL mediated vascular endothelial cells apoptosis through targeting GSK-3β via recruiting EZH2.

作者信息

Wang Minghui, Liu Yujie, Li Chao, Zhang Ying, Zhou Xiujun, Lu Chengzhi

机构信息

Tianjin Medical University Tianjin 300070, China.

Department of Cardiology, Tianjin Chest Hospital Tianjin 300222, China.

出版信息

Am J Transl Res. 2019 Mar 15;11(3):1827-1834. eCollection 2019.

PMID:30972206
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6456540/
Abstract

An increasing amount of research is demonstrating the role of long noncoding RNAs (lncRNAs) in human cardiovascular disease, and in particular, atherosclerosis. To date, the mechanism through which lncRNA OIP5-AS1 regulates the oxidative low-density lipoprotein (ox-LDL)-mediated endothelial cell apoptosis is still unclear. Results from this study found that lncRNA OIP5-AS1 was significantly over-expressed in the human umbilical vein endothelial cells (HUVECs) administered with ox-LDL. The silencing of OIP5-AS1 inhibited apoptosis and promoted proliferation via inducing G0/G1 cycle arrest. Chromatin immunoprecipitate (ChIP) revealed that lncRNA OIP5-AS1 reduced GSK-3β expression through recruiting EZH2, a critical element of the Polycomb Repressive Complex 2 (PRC2) complex that directly bind with the GSK-3β promoter region. Rescue experiments validated that GSK-3β could eliminate the effect of OIP5-AS1 on HUVECs. Overall, these findings suggest that lncRNA OIP5-AS1 accelerates ox-LDL mediated vascular endothelial cell apoptosis through targeting GSK-3β via recruiting EZH2, providing potential therapeutic strategies for atherosclerosis.

摘要

越来越多的研究表明长链非编码RNA（lncRNAs）在人类心血管疾病，尤其是动脉粥样硬化中所起的作用。迄今为止，lncRNA OIP5-AS1调节氧化型低密度脂蛋白（ox-LDL）介导的内皮细胞凋亡的机制仍不清楚。本研究结果发现，在给予ox-LDL的人脐静脉内皮细胞（HUVECs）中，lncRNA OIP5-AS1显著过表达。沉默OIP5-AS1可通过诱导G0/G1期阻滞抑制细胞凋亡并促进细胞增殖。染色质免疫沉淀（ChIP）显示，lncRNA OIP5-AS1通过招募EZH2来降低GSK-3β的表达，EZH2是多梳抑制复合物2（PRC2）的关键元件，可直接与GSK-3β启动子区域结合。拯救实验证实，GSK-3β可消除OIP5-AS1对HUVECs的影响。总体而言，这些发现表明lncRNA OIP5-AS1通过招募EZH2靶向GSK-3β，加速ox-LDL介导的血管内皮细胞凋亡，为动脉粥样硬化提供了潜在的治疗策略。