长链非编码RNA OIP5-AS1在癌症发生发展中的作用。
The role of lncRNA OIP5-AS1 in cancer development and progression.
作者信息
Zheng Cheng, Chu Man, Chen Qiuli, Chen Cheng, Wang Zhi-Wei, Chen Xiao
机构信息
The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China.
Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325027, Zhejiang, China.
出版信息
Apoptosis. 2022 Jun;27(5-6):311-321. doi: 10.1007/s10495-022-01722-3. Epub 2022 Mar 22.
OIP5-AS1, a conserved lncRNA, has been reported to be involved in several biological and pathological processes, including oncogenesis. OIP5-AS1 exerts its oncogenic or antitumor functions via regulation of different miRNAs in various cancer types. In this review, we describe the dysregulation of OIP5-AS1 expression in a variety of human cancers. Moreover, we discuss the multiple functions of OIP5-AS1 in cancer, including in proliferation, apoptosis, autophagy, ferroptosis, cell cycle, migration, metastasis, invasion, epithelial to mesenchymal transition, angiogenesis, cancer stem cells and drug resistance. Furthermore, we provide a future perspective for OIP5-AS1 research. We conclude that targeting OIP5-AS1 might be a promising cancer therapy approach.
OIP5-AS1是一种保守的长链非编码RNA，据报道它参与了包括肿瘤发生在内的多种生物学和病理过程。OIP5-AS1通过调控不同癌症类型中的不同微小RNA发挥其致癌或抗肿瘤功能。在这篇综述中，我们描述了OIP5-AS1在多种人类癌症中的表达失调情况。此外，我们讨论了OIP5-AS1在癌症中的多种功能，包括在增殖、凋亡、自噬、铁死亡、细胞周期、迁移、转移、侵袭、上皮-间质转化、血管生成、癌症干细胞和耐药性方面的功能。此外，我们为OIP5-AS1的研究提供了未来展望。我们得出结论，靶向OIP5-AS1可能是一种有前景的癌症治疗方法。
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