γ干扰素增强巨噬细胞中肿瘤坏死因子/恶病质素、白细胞介素1和尿激酶基因的转录，这些基因受短命阻遏物的调控。
Gamma interferon enhances macrophage transcription of the tumor necrosis factor/cachectin, interleukin 1, and urokinase genes, which are controlled by short-lived repressors.
作者信息
Collart M A, Belin D, Vassalli J D, de Kossodo S, Vassalli P
出版信息
J Exp Med. 1986 Dec 1;164(6):2113-8. doi: 10.1084/jem.164.6.2113.
Abstract
Exposure of mouse resident and thioglycollate-elicited peritoneal macrophages to IFN-gamma leads to a marked increase in the TNF-alpha (tumor necrosis factor/cachectin), IL-1 and u-PA (urokinase-type plasminogen activator) mRNA levels. Nuclear run-on experiments show that IFN-gamma acts by enhancing the transcription of these three genes. Transcription of these three genes is also rapidly and transiently induced by cycloheximide, an inhibitor of protein synthesis, indicating that they are under the control of short-lived repressors.
摘要
将小鼠驻留的和经巯基乙酸盐诱导的腹腔巨噬细胞暴露于γ干扰素下，会导致肿瘤坏死因子α（肿瘤坏死因子/恶病质素）、白细胞介素-1和尿激酶型纤溶酶原激活剂（u-PA）的mRNA水平显著升高。细胞核连续转录实验表明，γ干扰素通过增强这三个基因的转录起作用。这三个基因的转录也会被蛋白质合成抑制剂放线菌酮迅速且短暂地诱导，表明它们受短命阻遏物的控制。
相似文献
1
Gamma interferon enhances macrophage transcription of the tumor necrosis factor/cachectin, interleukin 1, and urokinase genes, which are controlled by short-lived repressors.γ干扰素增强巨噬细胞中肿瘤坏死因子/恶病质素、白细胞介素1和尿激酶基因的转录，这些基因受短命阻遏物的调控。
J Exp Med. 1986 Dec 1;164(6):2113-8. doi: 10.1084/jem.164.6.2113.
2
3
Biochemical events accompanying macrophage activation and the inhibition of colony-stimulating factor-1-induced macrophage proliferation by tumor necrosis factor-alpha, interferon-gamma, and lipopolysaccharide.伴随巨噬细胞活化以及肿瘤坏死因子-α、γ-干扰素和脂多糖对集落刺激因子-1诱导的巨噬细胞增殖抑制作用的生化事件。
J Cell Physiol. 1992 Jun;151(3):630-41. doi: 10.1002/jcp.1041510324.
4
Effect of gamma interferon on cachectin expression by mononuclear phagocytes. Reversal of the lpsd (endotoxin resistance) phenotype.γ干扰素对单核吞噬细胞恶病质素表达的影响。内毒素耐受（Lpsd）表型的逆转。
J Exp Med. 1986 Nov 1;164(5):1791-6. doi: 10.1084/jem.164.5.1791.
5
Interferon gamma and interleukin 2 synergize to induce selective monokine expression in murine peritoneal macrophages.
J Biol Chem. 1990 Apr 25;265(12):7036-41.
6
Gamma-interferon counteracts interleukin-1 alpha stimulated expression of urokinase-type plasminogen activator in human endothelial cells in vitro.
Biochem Biophys Res Commun. 1992 Oct 15;188(1):463-9. doi: 10.1016/0006-291x(92)92407-o.
7
Interferon-gamma overcomes glucocorticoid suppression of cachectin/tumor necrosis factor biosynthesis by murine macrophages.
J Clin Invest. 1990 Oct;86(4):1234-40. doi: 10.1172/JCI114829.
8
A labile repressor acts through the NFkB-like binding sites of the human urokinase gene.一种不稳定的阻遏物通过人尿激酶基因的类核因子κB结合位点发挥作用。
Nucleic Acids Res. 1991 Jun 25;19(12):3389-93. doi: 10.1093/nar/19.12.3389.
9
10
Selective inhibition of interleukin-1 beta gene expression in activated RAW 264.7 macrophages by interferon-gamma.干扰素-γ对活化的RAW 264.7巨噬细胞中白细胞介素-1β基因表达的选择性抑制作用。
Eur J Immunol. 1996 Jun;26(6):1253-9. doi: 10.1002/eji.1830260611.
引用本文的文献
1
Immune Modulatory Effects of PD-1/PD-L1 in Myasthenia Gravis: Insights From Peripheral Blood Mononuclear Cell Analysis.PD-1/PD-L1在重症肌无力中的免疫调节作用：来自外周血单个核细胞分析的见解
FASEB J. 2025 Aug 15;39(15):e70827. doi: 10.1096/fj.202500887R.
2
Role of Tumor Necrosis Factor in Tuberculosis.肿瘤坏死因子在结核病中的作用。
Biomolecules. 2025 May 12;15(5):709. doi: 10.3390/biom15050709.
3
Tuberculosis in otherwise healthy adults with inherited TNF deficiency.遗传性肿瘤坏死因子缺陷的健康成年人中的结核病。
Nature. 2024 Sep;633(8029):417-425. doi: 10.1038/s41586-024-07866-3. Epub 2024 Aug 28.
4
Immune-Mediated Neuropathies: Pathophysiology and Management.免疫介导性神经病：病理生理学与管理。
Int J Mol Sci. 2023 Apr 14;24(8):7288. doi: 10.3390/ijms24087288.
5
Bone Marrow Suppression Secondary to the COVID-19 Booster Vaccine: A Case Report.新型冠状病毒肺炎加强疫苗接种继发的骨髓抑制：一例报告
J Blood Med. 2022 Feb 18;13:69-74. doi: 10.2147/JBM.S350290. eCollection 2022.
6
Effect of water-soluble PM on the production of TNF-α by human monocytes and induction of apoptosis in A549 human lung epithelial cells.水溶性颗粒物对人单核细胞肿瘤坏死因子-α产生及A549人肺上皮细胞凋亡诱导的影响。
J Environ Health Sci Eng. 2021 Jan 7;19(1):143-150. doi: 10.1007/s40201-020-00588-4. eCollection 2021 Jun.
7
Localized Interleukin-12 for Cancer Immunotherapy.局部白介素-12 用于癌症免疫治疗。
Front Immunol. 2020 Oct 15;11:575597. doi: 10.3389/fimmu.2020.575597. eCollection 2020.
8
Comparative RNA-Seq transcriptome analyses reveal dynamic time-dependent effects of Fe, O, and Si irradiation on the induction of murine hepatocellular carcinoma.比较 RNA-Seq 转录组分析揭示了 Fe、O 和 Si 辐照对诱导小鼠肝癌的动态时间依赖性影响。
BMC Genomics. 2020 Jul 1;21(1):453. doi: 10.1186/s12864-020-06869-4.
9
MAP kinase phosphatase-1, a gatekeeper of the acute innate immune response.丝裂原活化蛋白激酶磷酸酶-1，急性先天免疫反应的守门员。
Life Sci. 2020 Jan 15;241:117157. doi: 10.1016/j.lfs.2019.117157. Epub 2019 Dec 16.
10
Potentiation of Cytokine-Mediated Restriction of Intracellular Replication by a Dot/Icm-Translocated Effector.效应蛋白介导的 Dot/Icm 易位增强细胞内复制的细胞因子限制。
J Bacteriol. 2019 Jun 21;201(14). doi: 10.1128/JB.00755-18. Print 2019 Jul 15.
本文引用的文献
1
Analysis of FBJ-MuSV provirus and c-fos (mouse) gene reveals that viral and cellular fos gene products have different carboxy termini.对FBJ-鼠肉瘤病毒前病毒和c-fos（小鼠）基因的分析表明，病毒和细胞的fos基因产物具有不同的羧基末端。
Cell. 1983 Apr;32(4):1241-55. doi: 10.1016/0092-8674(83)90306-9.
2
Nucleotide sequence of the retroviral leukemia gene v-myb and its cellular progenitor c-myb: the architecture of a transduced oncogene.逆转录病毒白血病基因v-myb及其细胞起源基因c-myb的核苷酸序列：一种转导癌基因的结构
Cell. 1982 Dec;31(2 Pt 1):453-63. doi: 10.1016/0092-8674(82)90138-6.
3
Cloning and characterization of different human sequences related to the onc gene (v-myc) of avian myelocytomatosis virus (MC29).与禽骨髓细胞瘤病毒（MC29）的癌基因（v-myc）相关的不同人类序列的克隆与特性分析。
Proc Natl Acad Sci U S A. 1982 Nov;79(21):6497-501. doi: 10.1073/pnas.79.21.6497.
4
Cloning and expression of murine interleukin-1 cDNA in Escherichia coli.小鼠白细胞介素-1 cDNA在大肠杆菌中的克隆与表达。
Nature. 1984;312(5993):458-62. doi: 10.1038/312458a0.
5
Two promoters of different strengths control the transcription of the mouse alpha-amylase gene Amy-1a in the parotid gland and the liver.两种不同强度的启动子控制着小鼠腮腺和肝脏中α-淀粉酶基因Amy-1a的转录。
Cell. 1983 Jun;33(2):501-8. doi: 10.1016/0092-8674(83)90431-2.
6
Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter.从含有噬菌体SP6启动子的质粒中高效体外合成生物活性RNA和RNA杂交探针。
Nucleic Acids Res. 1984 Sep 25;12(18):7035-56. doi: 10.1093/nar/12.18.7035.
7
Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene.对3T3细胞的刺激会诱导原癌基因c-fos的转录。
Nature. 1984;311(5985):433-8. doi: 10.1038/311433a0.
8
Transcriptional regulation of hemoglobin switching in chicken embryos.鸡胚中血红蛋白转换的转录调控。
Mol Cell Biol. 1981 Mar;1(3):281-8. doi: 10.1128/mcb.1.3.281-288.1981.
9
Secretion of plasminogen activator by stimulated macrophages.受刺激的巨噬细胞分泌纤溶酶原激活物。
J Exp Med. 1974 Apr 1;139(4):834-50. doi: 10.1084/jem.139.4.834.
10
Control of cachectin (tumor necrosis factor) synthesis: mechanisms of endotoxin resistance.恶病质素（肿瘤坏死因子）合成的调控：内毒素耐受机制
Science. 1986 May 23;232(4753):977-80. doi: 10.1126/science.3754653.
Zotero 插件