Grimaud J A, Borojevic R
J Submicrosc Cytol. 1986 Oct;18(4):783-93.
Thirty five cases of severe late chronic human schistosomiasis were studied. The attention was given to the portal vascular lesions. Four stages from isolated endothelial involvement to entire portal vein wall disorganization were observed. Ultrastructural evidence of smooth muscle cell dedifferentiation is noted with loss of well defined limits between periportal connective tissue and venous vascular wall. The synergistic action of hypertension, subendothelial transudation of serum and proliferation of vascular connective tissue cell lines, are considered to explain the self perpetuating character of portal fibrosis in chronic human schistosomiasis.
对35例晚期重度慢性人类血吸虫病患者进行了研究。重点关注门静脉血管病变。观察到从孤立的内皮受累到整个门静脉壁结构紊乱的四个阶段。注意到平滑肌细胞去分化的超微结构证据，门周结缔组织与静脉血管壁之间界限分明的界限消失。高血压、血清内皮下渗出和血管结缔组织细胞系增殖的协同作用被认为可以解释慢性人类血吸虫病门静脉纤维化的自我延续特征。
