Andrade Z A, Ramos E G, Dos Reis M G
Centro de Pesquisas Gonçalo Moniz-FIOCRUZ, Salvador, Brasil.
Mem Inst Oswaldo Cruz. 1988 Jul-Sep;83(3):323-33. doi: 10.1590/s0074-02761988000300009.
The pathology of schistosomiasis mansoni in rabbits was studied with special consideration to worm burden and duration of infection. Heavy and prolonged infections resulted in severe changes involving the intrahepatic portal vein branches, such as: polypoid endophlebitis, granulomatous endophlebitis and, later on, vascular occlusion and recanalization, vascular ectasia, fibrosis and hyalinization of the endothelial polyps. Living and dead adult worms, rather than the mature eggs, were the main pathogenetic factors. For some time the lesions tend to be limited to the portal vein branches, not extending to the periportal tissues, but, after 8 to 10 months, variable degree of portal, septal and intra-parenchymal fibrosis can be formed. However, both vascular and fibrotic changes in the liver had a focal distribution and therefore did not appear to cause portal hypertension and had no resemblance to the human pathology seen in cases of hepatosplenic schistosomiasis. Pathology of schistosomiasis in rabbits has peculiar aspects, which are worthwhile studying, since the model can be of interest for investigations, especially concerning the immunology and immunopathology of schistosomiasis mansoni.
对曼氏血吸虫病在兔体内的病理学进行了研究，特别考虑了虫负荷和感染持续时间。重度和长期感染导致肝内门静脉分支出现严重变化，如：息肉样静脉内膜炎、肉芽肿性静脉内膜炎，随后出现血管闭塞和再通、血管扩张、内皮息肉的纤维化和玻璃样变。活的和死的成虫而非成熟虫卵是主要致病因素。在一段时间内，病变往往局限于门静脉分支，不延伸至门周组织，但在8至10个月后，可形成不同程度的门静脉、间隔和实质内纤维化。然而，肝脏中的血管和纤维化变化呈局灶性分布，因此似乎不会导致门静脉高压，也与肝脾型血吸虫病患者的人体病理学表现不同。兔血吸虫病的病理学有其独特之处，值得研究，因为该模型对于研究，特别是关于曼氏血吸虫病的免疫学和免疫病理学研究可能具有重要意义。
