College of Life and Environmental Science, Wenzhou University, Wenzhou 325035, China.
College of Life and Environmental Science, Wenzhou University, Wenzhou 325035, China.
Int J Biol Macromol. 2019 Jun 15;131:1162-1170. doi: 10.1016/j.ijbiomac.2019.04.040. Epub 2019 Apr 8.
Diabetes is a complicated endocrine and metabolic disorder, which has become an epidemic health issue worldwide. Fucoidan is extensively distributed in the brown algae and several marine invertebrates exhibiting diverse biological activities. In the present study, the physicochemical property of Sargassum fusiforme fucoidan (SFF) and its effects on streptozotocin (STZ)-induced diabetic mice and gut microbiota were investigated. Diabetes mice not only showed abnormal blood glucose, but also accompanied by multiple symptoms, such as gradual emaciation, decreased body weight, increased food and water intake. Compared with diabetic mice after 6-week treatment, administration of SFF significantly decreased the fasting blood glucose, diet and water intake. Furthermore, SFF attenuated the pathological change in the heart and liver, improved the liver function, and suppressed oxidative stress in STZ-induced diabetic mice. Simultaneously, SFF significantly altered the gut microbiota in the faeces of diabetic mice, decreased the relative abundances of the diabetes-related intestinal bacteria, which is a potential mechanism for relieving the symptoms of diabetes. Therefore, SFF might be considered as one of the promising complementary and alternative medicines for the management of diabetes mellitus in future.
糖尿病是一种复杂的内分泌和代谢紊乱疾病，已成为全球范围内的流行健康问题。褐藻中的岩藻聚糖硫酸酯和几种海洋无脊椎动物中广泛分布，具有多种生物活性。本研究探讨了马尾藻岩藻聚糖硫酸酯（SFF）的理化性质及其对链脲佐菌素（STZ）诱导的糖尿病小鼠和肠道微生物群的影响。糖尿病小鼠不仅表现出异常的血糖水平，还伴有多种症状，如逐渐消瘦、体重减轻、食物和水摄入量增加。与糖尿病小鼠经过 6 周治疗后相比，SFF 给药显著降低了空腹血糖、饮食和水的摄入。此外，SFF 减轻了 STZ 诱导的糖尿病小鼠心脏和肝脏的病理变化，改善了肝功能，并抑制了氧化应激。同时，SFF 显著改变了糖尿病小鼠粪便中的肠道微生物群，降低了与糖尿病相关的肠道细菌的相对丰度，这是缓解糖尿病症状的潜在机制。因此，SFF 可能被认为是未来治疗糖尿病的有前途的补充和替代药物之一。
