Ye Jingyao, Liu Xuehong
Shandong University of Traditional Chinese Medicine, Jinan, China.
The Third School of Clinical Medicine of Guangzhou University of Chinese Medicine, Guangzhou, China.
Front Cell Dev Biol. 2022 Jun 27;10:913110. doi: 10.3389/fcell.2022.913110. eCollection 2022.
Macrophages (), as immune cells, play a pivotal role against pathogens and many diseases, such as cancer, inflammation, cardiovascular diseases, orthopedic diseases, and metabolic disorders. In recent years, an increasing number of studies have shown that small extracellular vesicles (sEVs) derived from (M-sEVs) play important roles in these diseases, suggesting that carry out their physiological functions through sEVs. This paper reviews the mechanisms underlying M-sEVs production different forms of polarization and their biological functions in multiple diseases. In addition, the prospects of M-sEVs in disease diagnosis and treatment are described.
巨噬细胞作为免疫细胞，在抵御病原体以及对抗许多疾病（如癌症、炎症、心血管疾病、骨科疾病和代谢紊乱）方面发挥着关键作用。近年来，越来越多的研究表明，源自巨噬细胞的小细胞外囊泡（M-sEVs）在这些疾病中发挥重要作用，这表明巨噬细胞通过小细胞外囊泡来执行其生理功能。本文综述了M-sEVs产生的机制、不同形式的极化及其在多种疾病中的生物学功能。此外，还描述了M-sEVs在疾病诊断和治疗中的前景。
