Laboratory of Biology and Modeling of the Cell, Ecole Normale Supérieure de Lyon, CNRS, Université Claude Bernard Lyon 1, 69007 Lyon, France.
Cells. 2019 Apr 10;8(4):339. doi: 10.3390/cells8040339.
Cellular adaptation to environmental stress relies on a wide range of tightly controlled regulatory mechanisms, including transcription. Changes in chromatin structure and organization accompany the transcriptional response to stress, and in some cases, can impart memory of stress exposure to subsequent generations through mechanisms of epigenetic inheritance. In the budding yeast , histone post-translational modifications, and in particular histone methylation, have been shown to confer transcriptional memory of exposure to environmental stress conditions through mitotic divisions. Recent evidence from also implicates histone methylation in transgenerational inheritance of stress responses, suggesting a more widely conserved role in epigenetic memory.
细胞对环境压力的适应依赖于广泛的严格控制的调节机制，包括转录。染色质结构和组织的变化伴随着对压力的转录反应，在某些情况下，可以通过表观遗传遗传机制将压力暴露的记忆传递给后代。在 budding yeast 中，组蛋白的翻译后修饰，特别是组蛋白甲基化，已经被证明可以通过有丝分裂分裂赋予对环境压力条件的转录记忆。最近来自 的证据也表明组蛋白甲基化在压力反应的跨代遗传中起作用，这表明它在表观遗传记忆中具有更广泛的保守作用。
