Aslam Maria, Tufail Tabussam, Almehmadi Yousaf, Abualamah Wajd Abdullatif, Alzahrani Abdullah R, Shahid Imran
University Institute of Diet and Nutritional Sciences UIDNS, The University of Lahore UOL, Lahore, Pakistan.
Faculty of Medicine, Rabigh-King Abdulaziz University, Rabigh, Saudi Arabia.
Front Nutr. 2025 Jul 17;12:1623478. doi: 10.3389/fnut.2025.1623478. eCollection 2025.
Metabolic syndrome (MetS) is a growing global health concern and a major risk factor for conditions such as diabetic nephropathy and atherosclerosis. It is marked by chronic inflammation, insulin resistance, and dyslipidemia. Dietary interventions, including carbohydrate-controlled diets, have shown potential in improving metabolic outcomes. (cumin), containing the bioactive compound cuminaldehyde, is known for its hypoglycemic and antioxidant properties.
This study aimed to evaluate the combined effect of a carbohydrate-controlled diet and cumin herbal infusion on metabolic and biochemical parameters in patients with metabolic syndrome.
A pre- and post-interventional study was conducted on 132 patients (aged 18-60 years) diagnosed with MetS based on the ATP III criteria. Participants were recruited from the University of Lahore Teaching Hospital (ULTH) through purposive sampling and were randomly assigned to control and intervention groups ( = 66 each). The intervention group (INEG) received a carbohydrate-controlled diet and cumin herbal infusion for 8 weeks. Anthropometric, biochemical, and physiological parameters were assessed at baseline and post-intervention. A two-way repeated measures ANOVA was used for statistical analysis.
Significant improvements were observed in body mass index (BMI), body weight, and lipid profile parameters ( < 0.005). The intervention group showed notable reductions in triglycerides, low-density lipoprotein (LDL), and fasting blood glucose levels compared to the control group (CG).
A carbohydrate-controlled diet combined with cumin herbal infusion may support glycemic control and improve lipid metabolism in individuals with metabolic syndrome. This combined approach shows potential as an adjunct dietary strategy for managing cardiometabolic risk factors.
代谢综合征（MetS）是一个日益引起全球关注的健康问题，也是糖尿病肾病和动脉粥样硬化等疾病的主要危险因素。它的特征是慢性炎症、胰岛素抵抗和血脂异常。包括碳水化合物控制饮食在内的饮食干预已显示出改善代谢结果的潜力。孜然含有生物活性化合物枯茗醛，以其降血糖和抗氧化特性而闻名。
本研究旨在评估碳水化合物控制饮食与孜然草药浸液对代谢综合征患者代谢和生化参数的联合作用。
对132名根据ATP III标准诊断为MetS的患者（年龄18 - 60岁）进行干预前后研究。通过目的抽样从拉合尔大学教学医院（ULTH）招募参与者，并随机分为对照组和干预组（每组 = 66人）。干预组（INEG）接受碳水化合物控制饮食和孜然草药浸液，为期8周。在基线和干预后评估人体测量、生化和生理参数。采用双向重复测量方差分析进行统计分析。
观察到体重指数（BMI）、体重和血脂参数有显著改善（P < 0.005）。与对照组（CG）相比，干预组的甘油三酯、低密度脂蛋白（LDL）和空腹血糖水平显著降低。
碳水化合物控制饮食与孜然草药浸液相结合可能有助于代谢综合征患者的血糖控制并改善脂质代谢。这种联合方法显示出作为管理心脏代谢危险因素的辅助饮食策略的潜力。
