1例视网膜母细胞瘤经质子束放射治疗后导致眼球痨。
A case of retinoblastoma resulting in phthisis bulbi after proton beam radiation therapy.
作者信息
Nakagawa Norihiko, Morimoto Takeshi, Miyamura Takako, Suzuki Shigenobu, Shimojo Hiroshi, Nishida Kohji
机构信息
Department of Ophthalmology, Osaka University Graduate School of Medicine, Osaka, Japan.
Department of Pediatrics, Osaka University Graduate School of Medicine, Osaka, Japan.
出版信息
Am J Ophthalmol Case Rep. 2022 Sep 29;28:101715. doi: 10.1016/j.ajoc.2022.101715. eCollection 2022 Dec.
PURPOSE
Proton beam radiation therapy (PBRT) is a treatment option for advanced retinoblastoma (RB) resistant to chemotherapy and focal ophthalmic treatment. Here we report a case of RB with phthisis bulbi following PBRT.
OBSERVATIONS
A 16-day-old boy with a family history of RB was referred to our institution. Initial examination revealed an extensive white mass in the right eye and a small tumor near the optic disk of the left eye. The patient was diagnosed with bilateral RB and treated with chemotherapy and focal ophthalmic therapy. The right eye showed shrinkage in the treatment course. The tumor control was not achieved bilaterally, and, therefore, PBRT was performed to preserve the eyes. However, the right eye became significantly phthisical following PBRT and ultimately required enucleation.
CONCLUSIONS AND IMPORTANCE
PBRT for RB may result in phthisis bulbi. Further investigations of its role and possible complications are warranted.
目的
质子束放射治疗（PBRT）是对化疗和局部眼科治疗耐药的晚期视网膜母细胞瘤（RB）的一种治疗选择。在此，我们报告一例PBRT后出现眼球痨的RB病例。
观察结果
一名有RB家族史的16日龄男婴被转诊至我院。初次检查发现右眼有广泛的白色肿物，左眼视盘附近有一个小肿瘤。该患者被诊断为双侧RB，并接受了化疗和局部眼科治疗。右眼在治疗过程中出现萎缩。双侧均未实现肿瘤控制，因此，进行PBRT以保留眼球。然而，PBRT后右眼明显萎缩，最终需要眼球摘除术。
结论与意义
RB的PBRT可能导致眼球痨。有必要对其作用和可能的并发症进行进一步研究。
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