Im Soyoung, Park Hong Sik, Cho Uiju, La Tae Yoon
Department of Hospital Pathology, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Seoul 16247, Republic of Korea.
Department of Ophthalmology and Visual Science, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Seoul 16247, Republic of Korea.
Diagnostics (Basel). 2022 Dec 8;12(12):3090. doi: 10.3390/diagnostics12123090.
Massive retinal gliosis (MRG) is a rare condition of non-neoplastic glial proliferation, which forms massive lesions that fill the eye. MRG is commonly associated with phthisis bulbi (a non-functional eye), congenital anomalies, or malformations. Herein, we report a case of massive retinal gliosis associated with a traumatic phthisis bulbi, which was initially mistaken as a malignant intraocular tumor and confirmed only after an eye enucleation. A 70-year-old woman presented with a protruding ocular mass in her left eye which had slowly grown for a year. She had phthisis bulbi in her left eye due to trauma during her childhood. An orbital CT revealed an intraocular mass lesion with calcifications, raising the possibility of retinoblastoma or other malignant intraocular tumors. Enucleation of the left eye globe was performed. Histopathologic examination revealed exuberant proliferation of the glial cells, metaplastic bone formation, hyalinized vessels, and hyperplasia of the retinal pigment epithelium, confirming the diagnosis of MRG. Although rare, the possibility of MRG should be considered as a differential diagnosis when encountering an intraocular mass lesion, as it can be misdiagnosed as a malignant tumor.
巨大视网膜胶质增生症（MRG）是一种罕见的非肿瘤性胶质细胞增生性疾病，可形成充满眼球的巨大病变。MRG通常与眼球痨（无功能的眼睛）、先天性异常或畸形相关。在此，我们报告一例与外伤性眼球痨相关的巨大视网膜胶质增生症病例，该病例最初被误诊为恶性眼内肿瘤，直到眼球摘除术后才得以确诊。一名70岁女性，左眼出现突出的眼内肿块，已缓慢生长一年。她左眼因童年时期的外伤而患有眼球痨。眼眶CT显示眼内有一个伴有钙化的肿块病变，增加了视网膜母细胞瘤或其他恶性眼内肿瘤的可能性。遂进行了左眼眼球摘除术。组织病理学检查显示胶质细胞增生旺盛、化生骨形成、血管玻璃样变性以及视网膜色素上皮增生，确诊为MRG。尽管罕见，但在遇到眼内肿块病变时，应考虑MRG作为鉴别诊断的可能性，因为它可能被误诊为恶性肿瘤。
