Luderer Mathias, Kaplan-Wickel Nurcihan, Sick Christian, Richter Agnes, Reinhard Iris, Kiefer Falk, Weber Tillmann
Klinik für Psychiatrie, Psychosomatik und Psychotherapie, Universitätsklinikum, Goethe-Universität Frankfurt, Heinrich-Hoffmann-Straße 10, 60528, Frankfurt am Main, Deutschland.
Klinik für Abhängiges Verhalten und Suchtmedizin, Zentralinstitut für Seelische Gesundheit, Medizinische Fakultät Mannheim, Universität Heidelberg, Mannheim, Deutschland.
Nervenarzt. 2019 Nov;90(11):1156-1161. doi: 10.1007/s00115-019-0706-6.
Routine screening using self report questionnaires for attention deficit/hyperactivity disorder (ADHD) in patients with alcohol use disorder is recommended due to its high prevalence and the time-consuming and demanding diagnostic assessment. The psychometric properties of such self-report instruments have hardly been investigated in this patient group.
The performance of the ADHD self-report scale (ADHD-SR) and the German short form of the Wender Utah Rating Scale (WURS-k) was determined in 402 patients with alcohol dependence during long-term residential weaning treatment. The diagnosis of adult ADHD had been confirmed in 85 of these patients using an extensive, standardized diagnostic procedure.
The ADHD-SR at a cut-off ≥15 showed the best psychometric properties (sensitivity 75.3%, specificity 94.0%, positive predictive value, PPV 77.1%, negative predictive value, NPV 93.4%). The results of the WURS-k were unsatisfactory at the established cut-off ≥30 and also at lower cut-offs with more false positive screening results compared to the ADHD-SR. The combination of both instruments (ADHD-SR ≥ 15 and/or WURS-k ≥ 30) increased sensitivity (86.9%) albeit at the expense of a higher rate of false positive screening results (specificity 87.7%, PPV 65.2%).
The ADHD-SR is a suitable instrument for routine screening of ADHD in alcohol dependent patients. To improve sensitivity, a lower cut-off (≥15) should be applied. The WURS-k as a single screening instrument cannot be recommended in alcohol dependent patients. If a higher sensitivity is desired, a combination of ADHD-SR and WURS-k is feasible.
由于注意力缺陷多动障碍(ADHD)在酒精使用障碍患者中患病率较高,且诊断评估耗时费力,因此建议使用自我报告问卷对酒精使用障碍患者进行ADHD常规筛查。但这类自我报告工具在该患者群体中的心理测量特性几乎未被研究过。
在402例酒精依赖患者接受长期住院戒酒治疗期间,对ADHD自我报告量表(ADHD-SR)和温德犹他评定量表德语简版(WURS-k)的性能进行了测定。其中85例患者通过广泛的标准化诊断程序确诊为成人ADHD。
ADHD-SR临界值≥15时显示出最佳心理测量特性(敏感性75.3%,特异性94.0%,阳性预测值77.1%,阴性预测值93.4%)。与ADHD-SR相比,WURS-k在既定临界值≥30时结果不理想,在较低临界值时假阳性筛查结果更多。两种工具联合使用(ADHD-SR≥15和/或WURS-k≥30)可提高敏感性(86.9%),尽管会导致假阳性筛查结果率升高(特异性87.7%,阳性预测值65.2%)。
ADHD-SR是酒精依赖患者ADHD常规筛查的合适工具。为提高敏感性,应采用较低临界值(≥15)。不建议将WURS-k作为酒精依赖患者的单一筛查工具。如果需要更高的敏感性,ADHD-SR和WURS-k联合使用是可行的。