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重症监护中促进器官捐献的决策支持:德国重症监护与急诊医学跨学科协会(DIVI)伦理委员会及器官捐献与移植委员会与德国医学重症监护与急诊医学学会(DGIIN)伦理委员会合作发布的立场文件

[Decision-making support in Intensive Care to facilitate organ donation : Position paper of the Ethics Section and the Organ Donation and Transplantation Section of the German Interdisciplinary Association of Critical Care and Emergency Medicine (DIVI) in collaboration with the Ethics Section of the German Society of Medical Intensive Care Medicine and Emergency Medicine (DGIIN)].

作者信息

Neitzke G, Rogge A, Lücking K M, Böll B, Burchardi H, Dannenberg K, Duttge G, Dutzmann J, Erchinger R, Gretenkort P, Hartog C, Jöbges S, Knochel K, Liebig M, Meier S, Michalsen A, Michels G, Mohr M, Nauck F, Salomon F, Seidlein A-H, Söffker G, Stopfkuchen H, Janssens U

机构信息

Institut für Geschichte, Ethik und Philosophie der Medizin, Medizinische Hochschule Hannover, Hannover, Deutschland.

Klinische Ethikberatung, Universitätsklinikum Schleswig-Holstein Campus Kiel, Kiel, Deutschland.

出版信息

Med Klin Intensivmed Notfmed. 2019 May;114(4):319-326. doi: 10.1007/s00063-019-0578-3.

Abstract

BACKGROUND AND CHALLENGE

Injuries, especially traumatic brain injury, or specific illnesses and their respective sequelae can result in the demise of the patients afflicted despite all efforts of modern intensive care medicine. If in principle organ donation is an option after a patient's death, intensive therapeutic measures are regularly required in order to maintain the homeostasis of the organs. These measures, however, cannot benefit the patient afflicted anymore-which in turn might lead to an ethical conflict between dignified palliative care for him/her and expanded intensive treatment to facilitate organ donation for others, especially if the patient has opted for the limitation of life-sustaining therapies in an advance directive.

METHOD

The Ethics Section and the Organ Donation and Transplantation Section of the German Interdisciplinary Association of Critical Care and Emergency Medicine (DIVI) have convened several meetings and a telephone conference and have arrived at a decision-making aid as to the extent of treatment for potential organ donors. This instrument focusses first on the assessment of five individual dimensions regarding organ donation, namely the certitude of a complete and irreversible loss of all brain function, the patient's wishes as to organ donation, his or her wishes as to limiting life-sustaining therapies, the intensity of expanded intensive treatment for organ protection and the odds of its successful attainment. Then, the combination of the individual assessments, as graphically shown in a {Netzdiagramm}, will allow for a judgement as to whether a continuation or possibly an expansion of intensive care measures is ethically justified, questionable or even inappropriate.

RESULT

The aid described can help mitigate ethical conflicts as to the extent of intensive care treatment for moribund patients, when organ donation is a medically sound option. NOTE: Gerald Neitzke und Annette Rogge contributed equally to this paper and should be considered co-first authors.

摘要

背景与挑战

损伤,尤其是创伤性脑损伤,或特定疾病及其各自的后遗症,尽管现代重症医学竭尽全力,仍可能导致患病患者死亡。如果原则上患者死亡后器官捐献是一种选择,那么通常需要采取强化治疗措施来维持器官的内环境稳定。然而,这些措施对患病患者已不再有益,这反过来可能导致在为其提供尊严的姑息治疗与为促进他人器官捐献而扩大强化治疗之间产生伦理冲突,尤其是当患者在预先指示中选择限制维持生命的治疗时。

方法

德国重症与急诊医学跨学科协会(DIVI)的伦理委员会以及器官捐献与移植委员会召开了多次会议和一次电话会议,并就潜在器官捐献者的治疗范围达成了一项决策辅助工具。该工具首先关注关于器官捐献的五个个体维度的评估,即所有脑功能完全且不可逆转丧失的确定性、患者对器官捐献的意愿、其对限制维持生命治疗的意愿、为保护器官而进行的强化治疗的强度以及成功实现的几率。然后,如{网络图}中以图形方式所示的个体评估的组合,将允许判断继续或可能扩大重症监护措施在伦理上是否合理、有疑问甚至不适当。

结果

所描述的辅助工具有助于在器官捐献是医学上合理选择的情况下,减轻关于濒死患者重症监护治疗范围的伦理冲突。注意:杰拉尔德·奈茨克和安妮特·罗格对本文贡献相同,应被视为共同第一作者。

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