Kim Hyun-Seok, El-Serag Hashem B
Section of Gastroenterology and Hepatology, Baylor College of Medicine, 7200 Cambridge Street, Houston, TX, 77030, USA.
U.S. Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX, USA.
Curr Gastroenterol Rep. 2019 Apr 11;21(4):17. doi: 10.1007/s11894-019-0681-x.
To discuss current knowledge and recent findings regarding the epidemiology of hepatocellular carcinoma (HCC) in the USA.
The US incidence rate of HCC is increasing, although the pace may have somewhat slowed since 2010. In 2012, incidence rates of HCC in Hispanics surpassed those of Asians. The recent epidemiological changes in major risk factors for HCC include increasing hepatitis C virus post-sustained virologic response, suppressed hepatitis B virus on nucleoside analogues, and alcoholic and non-alcoholic fatty liver disease. Non-alcoholic fatty liver disease has the greatest proportion of the burden of the main risk factors for HCC in the USA, followed by alcoholic liver disease, and hepatitis C virus and hepatitis B virus infections. This review focuses on current knowledge regarding the recent epidemiological trends in HCC, with an emphasis on future directions.
讨论美国肝细胞癌（HCC）流行病学的当前知识和最新发现。
美国HCC发病率呈上升趋势，尽管自2010年以来增速有所放缓。2012年，西班牙裔HCC发病率超过了亚裔。HCC主要危险因素最近的流行病学变化包括丙型肝炎病毒持续病毒学应答后发病率上升、核苷类似物抑制乙型肝炎病毒以及酒精性和非酒精性脂肪性肝病。在美国，非酒精性脂肪性肝病在HCC主要危险因素负担中所占比例最大，其次是酒精性肝病、丙型肝炎病毒和乙型肝炎病毒感染。本综述重点关注HCC近期流行病学趋势的当前知识，并强调未来方向。
