Evans R W, Gualtieri C T, Amara I
Psychopharmacology (Berl). 1986;90(2):211-6. doi: 10.1007/BF00181244.
Fourteen children with Attention Deficit Disorder with Hyperactivity (ADD + H) were administered the psychostimulant methylphenidate in a double-blind, placebo-controlled, crossover study. Subjects were evaluated on a well-validated measure of verbal memory and learning with an experimental design comprised of four conditions: placebo and active drug at three doses. Positive memory effects were found in the drug conditions. Significant dose-response relationships were found, indicating enhanced learning from placebo to low to medium to high dose. However, there was a differential drug effect on the memory task; methylphenidate selectively enhanced storage and retrieval mechanisms without affecting immediate acquisition.
在一项双盲、安慰剂对照的交叉研究中，对14名患有注意力缺陷多动障碍（ADD + H）的儿童施用了精神刺激药物哌甲酯。采用一种经过充分验证的言语记忆和学习测量方法，通过由四种情况组成的实验设计对受试者进行评估：安慰剂以及三种剂量的活性药物。在使用药物的情况下发现了积极的记忆效果。发现了显著的剂量反应关系，表明从安慰剂到低剂量、中剂量再到高剂量学习能力增强。然而，药物对记忆任务有不同的影响；哌甲酯选择性地增强了存储和检索机制，而不影响即时获取。
