Pereira Sofia S, Monteiro Mariana P, Antonini Sonir R, Pignatelli Duarte
Instituto de Investigação e Inovação em Saúde (I3S), Universidade do Porto, Porto, Portugal.
Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal.
Endocr Connect. 2019 May 1;8(5):R91-R104. doi: 10.1530/EC-19-0114.
Apoptosis evading is a hallmark of cancer. Tumor cells are characterized by having an impaired apoptosis signaling, a fact that deregulates the balance between cell death and survival, leading to tumor development, invasion and resistance to treatment. In general, patients with adrenocortical carcinomas (ACC) have an extremely bad prognosis, which is related to disease progression and significant resistance to treatments. In this report, we performed an integrative review about the disruption of apoptosis in ACC that may underlie the characteristic poor prognosis in these patients. Although the apoptosis has been scarcely studied in ACC, the majority of the deregulation phenomena already described are anti-apoptotic. Most importantly, in a near future, targeting apoptosis modulation in ACC patients may become a promising therapeutic.
逃避细胞凋亡是癌症的一个标志。肿瘤细胞的特征是细胞凋亡信号受损，这一事实打破了细胞死亡与存活之间的平衡，导致肿瘤发展、侵袭及对治疗产生抗性。一般来说，肾上腺皮质癌（ACC）患者的预后极差，这与疾病进展及对治疗的显著抗性有关。在本报告中，我们对ACC中细胞凋亡的破坏进行了综合综述，这可能是这些患者预后不良特征的潜在原因。尽管ACC中细胞凋亡的研究很少，但已描述的大多数失调现象都是抗凋亡的。最重要的是，在不久的将来，针对ACC患者的细胞凋亡调节可能会成为一种有前景的治疗方法。
