Department of Biological Science, Faculty of Science, Universiti Tunku Abdul Rahman, Bandar Barat, Kampar 31900, Perak, Malaysia.
Genomics Research Centre, Institute of Health and Biomedical Innovation and School of Biomedical Sciences, Queensland University of Technology, Musk Avenue, Kelvin Grove QLD 4059, Australia.
Medicina (Kaunas). 2019 Apr 11;55(4):101. doi: 10.3390/medicina55040101.
Numerous studies examined the association between factors FV, FVII, FXII, and FXIII-A gene polymorphisms and ischemic stroke, but conclusive evidence is yet to be obtained. Thus, this meta-analysis aimed to investigate the novel association of FV rs1800595, FVII rs5742910, FXII rs1801020, and FXIII-A rs5982 and rs3024477 polymorphisms with ischemic stroke risk. A systematic review was performed on articles retrieved before June 2018. Relevant data were extracted from eligible studies and meta-analyzed using RevMan version 5.3. The strength of association between studied polymorphisms and ischemic stroke risk was calculated as odds ratios and 95% confidence intervals, by applying both fixed- and random-effect models. A total of 25 studies involving 6100 ischemic stroke patients and 9249 healthy controls were incorporated in the final meta-analysis model. Specifically, rs1800595, rs5742910, rs1801020, rs5982, and rs3024477 consisted of 673, 3668, 922, 433, and 404 cases, as well as 995, 4331, 1285, 1321, and 1317 controls, respectively. The pooled analysis indicated that there was no significant association of FV rs1800595, FVII rs5742910, FXII rs1801020, FXIII-A rs5982, and rs3024477 polymorphisms with ischemic stroke risk, under any genetic models (dominant, recessive, over-dominant, and allelic). The present meta-analysis concluded that FV rs1800595, FVII rs5742910, FXII rs1801020, and FXIII-A rs5982 and rs3024477 polymorphisms are not associated with ischemic stroke risk.
大量研究探讨了 FV、FVII、FXII 和 FXIII-A 基因多态性与缺血性卒中之间的关联，但尚未得出明确的结论。因此，本荟萃分析旨在研究 FV rs1800595、FVII rs5742910、FXII rs1801020 和 FXIII-A rs5982 和 rs3024477 多态性与缺血性卒中风险的新关联。对 2018 年 6 月前检索到的文章进行了系统评价。从合格研究中提取相关数据，并使用 RevMan 版本 5.3 进行荟萃分析。应用固定效应模型和随机效应模型计算研究多态性与缺血性卒中风险之间的关联强度，计算比值比和 95%置信区间。最终荟萃分析模型纳入了 25 项研究，共涉及 6100 例缺血性卒中患者和 9249 例健康对照者。具体而言，rs1800595、rs5742910、rs1801020、rs5982 和 rs3024477 分别包含 673、3668、922、433 和 404 例病例以及 995、4331、1285、1321 和 1317 例对照者。汇总分析表明，FV rs1800595、FVII rs5742910、FXII rs1801020、FXIII-A rs5982 和 rs3024477 多态性与缺血性卒中风险之间没有显著关联，在任何遗传模型（显性、隐性、超显性和等位基因）下均如此。本荟萃分析的结论是，FV rs1800595、FVII rs5742910、FXII rs1801020 和 FXIII-A rs5982 和 rs3024477 多态性与缺血性卒中风险无关。
