Lee Yee Teng, Mohd Ismail Nor Ismaliza, Wei Loo Keat
Department of Biological Science, Faculty of Science, Universiti Tunku Abdul Rahman, Kampar, Perak, Malaysia.
PLoS One. 2021 Jan 13;16(1):e0245038. doi: 10.1371/journal.pone.0245038. eCollection 2021.
Ischemic stroke is one of the non-communicable diseases that contribute to the significant number of deaths worldwide. However, the relationship between microbiome and ischemic stroke remained unknown. Hence, the objective of this study was to perform systematic review on the relationship between human microbiome and ischemic stroke.
A systematic review on ischemic stroke was carried out for all articles obtained from databases until 22nd October 2020. Main findings were extracted from all the eligible studies.
Eighteen eligible studies were included in the systematic review. These studies suggested that aging, inflammation, and different microbial compositions could contribute to ischemic stroke. Phyla Firmicutes and Bacteroidetes also appeared to manipulate post-stroke outcome. The important role of microbiota-derived short-chain fatty acids and trimethylamine N-oxide in ischemic stroke were also highlighted.
This is the first systematic review that investigates the relationship between microbiome and ischemic stroke. Aging and inflammation contribute to differential microbial compositions and predispose individuals to ischemic stroke.
缺血性中风是导致全球大量死亡的非传染性疾病之一。然而，微生物群与缺血性中风之间的关系仍不清楚。因此，本研究的目的是对人类微生物群与缺血性中风之间的关系进行系统评价。
对截至2020年10月22日从数据库中获得的所有文章进行缺血性中风的系统评价。从所有符合条件的研究中提取主要发现。
18项符合条件的研究纳入了系统评价。这些研究表明，衰老、炎症和不同的微生物组成可能导致缺血性中风。厚壁菌门和拟杆菌门似乎也会影响中风后的预后。微生物群衍生的短链脂肪酸和氧化三甲胺在缺血性中风中的重要作用也得到了强调。
这是第一项调查微生物群与缺血性中风之间关系的系统评价。衰老和炎症导致微生物组成的差异，并使个体易患缺血性中风。
