Bocquet A, Dupont C, Chouraqui J-P, Darmaun D, Feillet F, Frelut M-L, Girardet J-P, Hankard R, Lapillonne A, Rozé J-C, Simeoni U, Turck D, Briend A
Association Française de Pédiatrie Ambulatoire (French association of ambulatory paediatrics), 33400 Talence, France; Université de Franche-Comté, 25000 Besançon, France.
Université de Paris Descartes, Hôpital Necker-Enfants-Malades, 75006 Paris, France; Clinique Marcel-Sembat, 92100 Boulogne, France.
Arch Pediatr. 2019 May;26(4):238-246. doi: 10.1016/j.arcped.2019.03.001. Epub 2019 Apr 9.
Foods for special medical purposes (FSMPs) with a protein fraction made of hydrolyzed rice protein (HRPs) have been on the market in Europe since the 2000s for the treatment of cow's milk protein allergy (CMPA). HRP formulas (HRPFs) are proposed as a plant-based alternative to cow's milk protein-based extensively hydrolyzed formulas (CMP-eHF) beside the soy protein formulas whose use in CMPA is controversial. HRPFs do not contain phytoestrogens and are derived from non-genetically modified rice. HRPFs are strictly plant-based apart from the addition of vitamin D (cholecalciferol). As the amino acid content of rice proteins differs from that of human milk proteins, the protein quality of these formulas is improved by supplementation with free lysine, threonine, and tryptophan. The consumption of HRPFs has risen: for example, in France HRPFs account for 4.9% in volume of all formulas for children aged 0-3 years. Several studies have shown the adequacy of HRPFs in treating CMPA. They ensure satisfactory growth from the 1st weeks of life for infants and toddlers, both in healthy children and in those with CMPA. HRPFs can be used to treat children with CMPA either straightaway or in second intention in cases of poor tolerance to CMP-eHF for organoleptic reasons or for lack of efficacy. In France, the cost of HRPFs is close to that of regular infant or follow-on formulas.
自21世纪初以来，含有水解大米蛋白（HRP）作为蛋白质成分的特殊医学用途食品（FSMP）在欧洲市场上用于治疗牛奶蛋白过敏（CMPA）。除了大豆蛋白配方奶粉（其在CMPA中的使用存在争议）之外，HRP配方奶粉（HRPF）被提议作为基于牛奶蛋白的深度水解配方奶粉（CMP-eHF）的植物性替代品。HRPF不含植物雌激素，且源自非转基因大米。除添加维生素D（胆钙化醇）外，HRPF严格基于植物。由于大米蛋白的氨基酸含量与人乳蛋白不同，通过补充游离赖氨酸、苏氨酸和色氨酸来提高这些配方奶粉的蛋白质质量。HRPF的消费量有所上升：例如，在法国，HRPF在0至3岁儿童所有配方奶粉的销量中占4.9%。多项研究表明HRPF在治疗CMPA方面是足够的。它们能确保婴儿和幼儿从生命的第一周起就有令人满意的生长，无论是健康儿童还是患有CMPA的儿童。HRPF可直接用于治疗患有CMPA的儿童，或者在因感官原因或缺乏疗效而对CMP-eHF耐受性差的情况下作为第二选择使用。在法国，HRPF的成本与普通婴儿配方奶粉或后续配方奶粉的成本相近。
