Hypertension in Africa Research Team (HART), North-West University, Private Bag X1290, Potchefstroom, 2520, South Africa.
MRC Research Unit: Hypertension and Cardiovascular Disease, North-West University, Potchefstroom, South Africa.
Curr Hypertens Rep. 2019 Apr 12;21(5):38. doi: 10.1007/s11906-019-0942-y.
This review synthesizes recent findings in humans pertaining to the relationships between marinobufagenin (MBG), a steroidal Na/K-ATPase inhibitor and salt-sensitivity biomarker, and early cardiovascular risk markers.
Twenty-four-hour urinary MBG strongly associates with habitual salt intake in young healthy adults (aged 20-30 years). Furthermore, in young healthy adults free of detected cardiovascular disease, MBG associates with increased large artery stiffness and left ventricular mass independent of blood pressure. These findings in human studies corroborate mechanistic data from rat studies whereby stimulation of MBG by a high salt intake or MBG infusion increased vascular fibrosis and cardiac hypertrophy. Twenty-four-hour urinary MBG may be a potential biomarker of early cardiovascular risk. Adverse associations between MBG-which increases with salt consumption-and early cardiovascular risk markers support the global efforts to reduce population-wide salt intake in an effort to prevent and control the burden of non-communicable diseases.
本文综合了近期有关海洋因(bufagenin, MBG)与盐敏感性生物标志物及心血管早期风险标志物之间关系的人类研究结果。
24 小时尿 MBG 与年轻健康成年人（年龄 20-30 岁）的习惯性盐摄入量密切相关。此外，在无明显心血管疾病的年轻健康成年人中，MBG 与大动脉僵硬度和左心室质量的增加独立于血压相关。这些人类研究结果与大鼠研究的机制数据相吻合，即高盐摄入或 MBG 输注刺激可增加血管纤维化和心脏肥大。24 小时尿 MBG 可能是心血管早期风险的潜在生物标志物。MBG 与盐摄入量增加之间的不良关联及其与心血管早期风险标志物之间的关联，支持全球减少人群盐摄入量的努力，以预防和控制非传染性疾病的负担。
