Department of Dermatology, Venerology and Allergology, Universitätsmedizin Mannheim, Ruprecht-Karls-Universits Heidelberg, Mannheim, Germany.
Zentrum fuer Lipoedem, Venen Und Aeesthetik, Linz, Austria.
J Cosmet Dermatol. 2019 Aug;18(4):1014-1019. doi: 10.1111/jocd.12953. Epub 2019 Apr 13.
Cryolipolysis combined with shockwave therapy has been previously shown to have synergistic effects in body contouring results.
This open-label, prospective, multicenter, comparative study investigated the safety and efficacy of combined cryolipolysis, shockwave therapy with cryolipolysis, shockwave therapy, and injection polyenylphosphatidylcholine-based lipolysis.
Enrolled patients were treated in the abdominal or flank area with cryolipolysis, shockwave therapy and injection lipolysis (n = 10) or cryolipolysis and shockwave therapy (n = 4). All treatments were conducted the same day. Evaluations were conducted 3 months after treatment and included histological analysis, standardized photography, blinded-investigator efficacy, and safety ratings, as well as patient ratings of satisfaction and tolerance.
Compared to baseline, the 3-month follow-up histological analysis revealed a more profound subcutaneous adipose tissue reaction with the triple combination therapy (cryolipolysis, injection lipolysis, radial shock wave) than with the double combination with regard to adipocyte damage and grade of inflammation. Waist circumference was significantly reduced in patients of both groups, but patients in the triple combination group were shown to have a significantly more pronounced reduction in subcutaneous fat. Factors that were shown to influence treatment outcome included baseline BMI and waist circumference. Age and gender had no effect. The abdominal area reacted better to the treatment compared to flanks. No significant side effects or adverse events were reported. The procedure was well-tolerated, and the majority of patients were satisfied with the treatment results.
Combination of cryolipolysis, radial shockwave, and injection lipolysis is a safe, well-tolerated treatment for reduction in subcutaneous fat.
冷冻溶脂联合冲击波治疗在身体塑形效果方面已显示出协同作用。
本开放性、前瞻性、多中心、对照研究调查了冷冻溶脂联合冲击波治疗、冷冻溶脂联合冲击波治疗、注射聚烯基磷酸胆碱脂肪分解术联合治疗的安全性和有效性。
招募的患者在腹部或侧腹部接受冷冻溶脂、冲击波治疗和注射脂肪分解术（n=10）或冷冻溶脂和冲击波治疗（n=4）。所有治疗均在同一天进行。治疗 3 个月后进行评估，包括组织学分析、标准化摄影、盲法研究者评估疗效和安全性，以及患者满意度和耐受性评分。
与基线相比，3 个月的随访组织学分析显示，三重联合治疗（冷冻溶脂、注射脂肪分解术、径向冲击波）与双重联合治疗（冷冻溶脂和径向冲击波）相比，在脂肪细胞损伤和炎症程度方面，皮下脂肪组织反应更为明显。两组患者的腰围均显著减小，但三重联合组患者的皮下脂肪减少更为明显。影响治疗效果的因素包括基线 BMI 和腰围。年龄和性别无影响。与侧腹相比，腹部区域对治疗的反应更好。未报告明显的副作用或不良事件。该过程耐受良好，大多数患者对治疗结果满意。
冷冻溶脂、径向冲击波和注射脂肪分解术联合治疗是一种安全、耐受良好的减少皮下脂肪的方法。
