Zhu Q, Hu T J, Shen J W, Shen J H, Chen W H, Gu S K, Lu H M
Immunoprophylaxis Department, Songjiang District Center for Disease Control and Prevention, Shanghai 201620, China.
Zhonghua Yu Fang Yi Xue Za Zhi. 2019 Apr 6;53(4):388-393. doi: 10.3760/cma.j.issn.0253-9624.2019.04.011.
To explore serum levels of measles and rubella IgG antibodies among mothers and infants. According to the inclusion and exclusion criteria, we selected 319 puerperae and their infants in maternal hospitals of Songjiang district November 2016 to February 2017, venous blood were collected and serum measles and rubella IgG antibodies were measured using ELISA. To study the correlation between the level of measles and rubella antibodies in infants and mothers' by using the Spearman's correlation analysis. The age at delivery was (29.71±4.25) years old; and the gestational age at delivery was (39.06±1.30) weeks. The positive rate and protection rate of measles antibody in puerperae were 82.5% (243/319) and 43.3% (135/319), the GMC [ ()] was 655.74 (251.21-1 299.02) mIU/ml. The positive rate of rubella antibody in puerperae was 61.1% (195/319), the GMC [ ()] was 31.34 (11.65-73.61) IU/ml. The positive rate and protection rate of measles antibody in infants were 84.1% (270/321) and 46.1% (148/321), the GMC [ ()] was 665.07 (279.63-1 544.07) mIU/ml. The positive rate of rubella antibody in infants was 69.5% (223/321), the GMC [ ()] was 40.30 (16.12-98.48) IU/ml. There was statistical difference in measles (-14.64, 0.001) and rubella (-8.66, 0.001) antibody levels between mothers and infants. There was positive correlation in measles (0.76, 0.001) and rubella (0.86, 0.001) antibody level between mothers and infants. The maternal antibody of measles and rubella had a concentration effect. The level of measles and rubella antibodies in the infants was higher than that in the mothers' and increased with the increase of the level of measles and rubella antibodies in the mothers.
探讨母婴血清中麻疹和风疹IgG抗体水平。根据纳入和排除标准，于2016年11月至2017年2月在松江区妇幼保健院选取319例产妇及其婴儿，采集静脉血，采用酶联免疫吸附测定法检测血清麻疹和风疹IgG抗体。采用Spearman相关分析研究婴儿与母亲体内麻疹和风疹抗体水平的相关性。产妇的分娩年龄为（29.71±4.25）岁；分娩孕周为（39.06±1.30）周。产妇麻疹抗体阳性率和保护率分别为82.5%（243/319）和43.3%（135/319），几何平均浓度[（）]为655.74（251.21 - 1299.02）mIU/ml。产妇风疹抗体阳性率为61.1%（195/319），几何平均浓度[（）]为31.34（11.65 - 73.61）IU/ml。婴儿麻疹抗体阳性率和保护率分别为84.1%（270/321）和46.1%（148/321），几何平均浓度[（）]为665.07（279.63 - 1544.07）mIU/ml。婴儿风疹抗体阳性率为69.5%（223/321），几何平均浓度[（）]为40.30（16.12 - 98.48）IU/ml。母婴之间麻疹（-14.64，0.001）和风疹（-8.66，0.001）抗体水平存在统计学差异。母婴之间麻疹（0.76，0.001）和风疹（0.86，0.001）抗体水平呈正相关。母亲的麻疹和风疹抗体具有浓度效应。婴儿体内麻疹和风疹抗体水平高于母亲，且随母亲体内麻疹和风疹抗体水平的升高而升高。
