Sisk C L, Bronson F H
Biol Reprod. 1986 Oct;35(3):554-61. doi: 10.1095/biolreprod35.3.554.
This experiment concerned the changing patterns in secretion of luteinizing hormone (LH), follicle-stimulating hormone (FSH), and growth hormone (GH) under conditions of food restriction and subsequent catch-up growth. Weanling male rats were given either restricted (4 g food/day) or unrestricted access to food until 60 days of age. At this age, food-restricted rats weighed only 25% as much as rats fed ad libitum. Food restriction resulted in a dramatic decrease in the frequency of LH and GH pulses, and in the amplitude of GH pulses. It also slightly but significantly decreased mean blood levels of FSH (which was not secreted in a pulsatile manner in 60-day-old controls fed ad libitum). When restricted rats were given unrestricted access to food, frequency of LH and GH pulses and mean levels of FSH increased significantly and simultaneously within 2 days in half of the animals. Only an additional 8-10% of their body weight decrement was recovered at this time. After 10 days of food restoration, when restricted rats still weighed 50% less than controls, their secretory patterns of all three hormones were not significantly different from those of controls. Thus, recovery of gonadotropin and GH secretion was relatively rapid. Except for the quantitatively lesser impact of food restriction on FSH secretion, there was no evidence of any priorities in the secretion of the three hormones. Under conditions of rapid catch-up growth, the secretory patterns of LH, FSH, and GH appeared to develop simultaneously.
本实验研究了在食物限制及随后的追赶生长条件下，促黄体生成素（LH）、促卵泡生成素（FSH）和生长激素（GH）分泌模式的变化。将断乳雄性大鼠分为两组，一组给予限食（每天4克食物），另一组自由进食，直至60日龄。此时，限食组大鼠体重仅为自由进食组大鼠的25%。食物限制导致LH和GH脉冲频率显著下降，GH脉冲幅度也显著下降。它还轻微但显著降低了FSH的平均血药浓度（在60日龄自由进食的对照组中，FSH并非以脉冲方式分泌）。当限食大鼠改为自由进食时，一半的动物在2天内LH和GH脉冲频率以及FSH平均水平同时显著增加。此时，它们仅额外恢复了体重下降的8 - 10%。食物恢复10天后，限食大鼠体重仍比对照组轻50%，但三种激素的分泌模式与对照组无显著差异。因此，促性腺激素和GH分泌的恢复相对较快。除了食物限制对FSH分泌的影响在数量上较小外，没有证据表明这三种激素的分泌存在任何优先级。在快速追赶生长的条件下，LH、FSH和GH的分泌模式似乎是同时发展的。
