National Center for Genetic Engineering and Biotechnology (BIOTEC) , 113 Thailand Science Park, Phaholyothin Road , Klong Luang , Pathumthani 12120 , Thailand.
J Nat Prod. 2019 May 24;82(5):1165-1176. doi: 10.1021/acs.jnatprod.8b00869. Epub 2019 Apr 15.
Thirty-one highly modified lanostanes (1-31), together with 19 known compounds (32-50), were isolated from fruiting bodies of the wood-rot basidiomycete Tomophagus sp. The structures were elucidated by analyses of HRMS and NMR spectroscopic data. The present work demonstrates the high structural diversity of modified lanostane triterpenoids from Tomophagus. This paper also discusses structural revisions of several known derivatives. Some of the isolated compounds exhibited moderate antimalarial activity against Plasmodium falciparum K1 (IC 5.1-19 μM).
从木质腐朽担子菌 Tomophagus sp 的子实体中分离得到 31 种高度修饰的羊毛甾烷（1-31），以及 19 种已知化合物（32-50）。通过分析高分辨质谱和核磁共振波谱数据阐明了这些化合物的结构。本研究表明 Tomophagus 来源的修饰羊毛甾烷三萜具有高度的结构多样性。本文还讨论了几种已知衍生物的结构修订。一些分离得到的化合物对恶性疟原虫 K1 表现出中等的抗疟活性（IC 5.1-19 μM）。
