Yao Jian-Neng, Chen Lin, Tang Yang, Chen He-Ping, Zhao Zhen-Zhu, Li Zheng-Hui, Feng Tao, Liu Ji-Kai
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, China.
University of Chinese Academy of Sciences, Beijing, China.
J Antibiot (Tokyo). 2017 Dec;70(12):1104-1111. doi: 10.1038/ja.2017.122. Epub 2017 Oct 25.
Twelve new lanostane triterpenoids, sterenoids A-L (1-12) have been isolated from fruiting bodies of the basidiomycete Stereum sp. Compounds 1-12 are rare 14(13→︀12)abeo-lanostane triterpenoids featuring remarkable 13R configurations that discriminate from the previously covered counterparts. Their structures and absolute configurations are assigned on the basis of in-depth one- and two-dimensional NMR spectroscopic analysis, as well as unbiased quantum chemical NMR and electronic CD calculations. All isolates are evaluated for their in vitro cytotoxicity against five human tumor cell lines. Compound 5 exhibits potent cytotoxic activities against tumor cell lines HL-60 and SMMC-7721 with IC values of 4.7 and 7.6 μM, respectively.
从担子菌纲真菌Stereum sp.的子实体中分离出了12种新的羊毛甾烷三萜类化合物，即甾体A-L（1-12）。化合物1-12是罕见的14(13→︀12)去甲羊毛甾烷三萜类化合物，具有显著的13R构型，与之前报道的同类化合物不同。它们的结构和绝对构型是基于深入的一维和二维核磁共振光谱分析，以及无偏量子化学核磁共振和电子圆二色计算确定的。对所有分离物进行了针对五种人类肿瘤细胞系的体外细胞毒性评估。化合物5对肿瘤细胞系HL-60和SMMC-7721表现出较强的细胞毒性活性，IC值分别为4.7和7.6 μM。
