Laboratory of the Biology of Addictive Diseases, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA.
Department of Psychiatry, Amsterdam Institute for Addiction Research, Academic Medical Center, University of Amsterdam, PO Box 22660, 1100 DD Amsterdam, The Netherlands.
Pharmacogenomics. 2019 Apr;20(5):331-341. doi: 10.2217/pgs-2018-0137. Epub 2019 Apr 15.
To determine if selected serotonergic and noradrenergic gene variants are associated with heroin addiction. A total of 126 variants in 19 genes in subjects with Dutch European ancestry from The Netherlands. Subjects included 281 opioid-dependent volunteers in methadone maintenance or heroin-assisted treatment, 163 opioid-exposed but not opioid-dependent volunteers who have been using illicit opioids but never became opioid-dependent and 153 healthy controls. Nominal associations were indicated for 20 variants in six genes including an experiment-wise significant association from the combined effect of three SNPs (rs363332, rs363334 and rs363338) with heroin dependence (p = 0.047). Further studies are warranted to confirm and elucidate the role of these variants in the vulnerability to opioid addiction.
确定选定的血清素能和去甲肾上腺素能基因变体是否与海洛因成瘾有关。 研究对象来自荷兰的荷兰欧洲血统的 126 名受试者，共涉及 19 个基因中的 126 个变体。受试者包括 281 名接受美沙酮维持治疗或海洛因辅助治疗的阿片类药物依赖者，163 名暴露于阿片类药物但未依赖于阿片类药物的志愿者，他们曾使用过非法阿片类药物，但从未成为阿片类药物依赖者，以及 153 名健康对照者。 在包括三个 SNP（rs363332、rs363334 和 rs363338）的联合效应在内的六个基因中的 20 个变体中，存在名义关联，与海洛因依赖的关联具有统计学意义（p=0.047）。 需要进一步的研究来证实和阐明这些变体在易感性中的作用。
