Fox K M, Tobin J D, Plato C C
Calcif Tissue Int. 1986 Oct;39(4):218-25. doi: 10.1007/BF02555207.
This longitudinal study was undertaken to ascertain the rate of bone loss and to identify aging, cohort and/or time effects on bone loss in male participants of the Baltimore Longitudinal Study of Aging. Hand-wrist radiographs were obtained from 1958-1981 and were evaluated for total width, medullary width, and length of the second metacarpal. Data were analyzed using an age-time matrix with 8-year intervals for three epochs and nine age groups. The bone measurements were analyzed in three perspectives (cross-sectional, longitudinal and time-series). The results demonstrate that there is both a cross-sectional and longitudinal loss of cortical bone with age in the second metacarpal. Furthermore, the results show that males lose approximately 14% of their cortical bone, at a rate of about 2% per decade, over the adult lifespan. The majority of this loss occurs between the ages of 45 and 69 and is due primarily to aging and is not an artifact of cohort differences or secular change.
这项纵向研究旨在确定骨质流失率，并识别巴尔的摩纵向衰老研究男性参与者骨质流失中的衰老、队列和/或时间效应。于1958年至1981年获取手腕X光片，并对第二掌骨的总宽度、髓腔宽度和长度进行评估。使用一个年龄-时间矩阵对数据进行分析，该矩阵有三个时期，间隔为8年，分为九个年龄组。从三个角度（横断面、纵向和时间序列）对骨测量值进行分析。结果表明，随着年龄增长，第二掌骨皮质骨存在横断面和纵向流失。此外，结果显示，在成年期，男性会流失约14%的皮质骨，流失速率约为每十年2%。这种流失的大部分发生在45岁至69岁之间，主要是由于衰老，而非队列差异或长期变化的假象。
